PARG

Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.[4][5][6]

PARG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPARG, PARG99, poly(ADP-ribose) glycohydrolase
External IDsOMIM: 603501 MGI: 1347094 HomoloGene: 50532 GeneCards: PARG
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q11.23Start49,818,279 bp[1]
End49,970,203 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8505

26430

Ensembl

ENSG00000227345

n/a

UniProt

Q86W56

O88622

RefSeq (mRNA)

NM_001303486
NM_001303487
NM_001303489
NM_003631
NM_001324381

NM_011960
NM_001359915
NM_001374221

RefSeq (protein)

NP_001290415
NP_001290416
NP_001290418
NP_001311310
NP_003622

NP_036090
NP_001346844
NP_001361150

Location (UCSC)Chr 10: 49.82 – 49.97 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.[4]

References
  1. GRCh38: Ensembl release 89: ENSG00000227345 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: Poly (ADP-ribose) glycohydrolase". Retrieved 2011-11-08.
  5. Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". J. Biol. Chem. 272 (18): 11895–901. doi:10.1074/jbc.272.18.11895. PMID 9115250.
  6. Amé JC, Apiou F, Jacobson EL, Jacobson MK (1999). "Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 85 (3–4): 269–70. doi:10.1159/000015310. PMID 10449915.

Further reading
  • Affar, E. B.; Germain, M.; Winstall, E.; Vodenicharov, M.; Shah, R. G.; Salvesen, G. S.; Poirier, G. G. (2000). "Caspase-3-mediated Processing of Poly(ADP-ribose) Glycohydrolase during Apoptosis". Journal of Biological Chemistry. 276 (4): 2935–2942. doi:10.1074/jbc.M007269200. PMID 11053413.
  • Ohashi, S.; Kanai, M.; Hanai, S.; Uchiumi, F.; Maruta, H.; Tanuma, S.; Miwa, M. (2003). "Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells". Biochemical and Biophysical Research Communications. 307 (4): 915–921. doi:10.1016/S0006-291X(03)01272-5. PMID 12878198.
  • Meyer, R. G.; Meyer-Ficca, M. L.; Jacobson, E. L.; Jacobson, M. K. (2003). "Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)". Gene. 314: 181–190. doi:10.1016/S0378-1119(03)00738-8. PMID 14527731.
  • Golovanov, A. P.; Barillà, D.; Golovanova, M.; Hayes, F.; Lian, L. Y. (2003). "ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure". Molecular Microbiology. 50 (4): 1141–1153. doi:10.1046/j.1365-2958.2003.03750.x. PMID 14622405.
  • Keil, C.; Petermann, E.; Oei, S. L. (2004). "Tannins elevate the level of poly(ADP–ribose) in HeLa cell extracts". Archives of Biochemistry and Biophysics. 425 (1): 115–121. doi:10.1016/j.abb.2004.02.024. PMID 15081900.
  • Meyer-Ficca, M. L.; Meyer, R. G.; Coyle, D. L.; Jacobson, E. L.; Jacobson, M. K. (2004). "Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments". Experimental Cell Research. 297 (2): 521–532. doi:10.1016/j.yexcr.2004.03.050. PMID 15212953.
  • Putt, K. S.; Hergenrother, P. J. (2004). "A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): Application to inhibitor identification and evaluation". Analytical Biochemistry. 333 (2): 256–264. doi:10.1016/j.ab.2004.04.032. PMID 15450800.
  • Bonicalzi, M. -E.; Haince, J. -F.; Droit, A.; Poirier, G. G. (2005). "Poly-ADP-ribosylation in health and disease". Cellular and Molecular Life Sciences. 62 (7–8): 739–750. doi:10.1007/s00018-004-4505-1. PMID 15868399.
  • Bonicalzi, M. È.; Gagné, J. P.; Gagné, P.; Ouellet, M. È.; Hendzel, M. J.; Poirier, G. G. (2005). "Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles". Biochemical Journal. 392 (3): 499–509. doi:10.1042/BJ20050792. PMC 1316289. PMID 16117724.

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