Mast cell stabilizer
Mast cell stabilizers are medications used to prevent or control certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine[1] and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.
As inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis.[2] Finally, in oral form, they are used to treat the rare condition of mastocytosis.
Examples
Mast cell stabilizer medications include:
- β2-adrenergic agonists
- Cromoglicic acid
- Ketotifen
- Loratidine
- Desloratidine
- Methylxanthines
- Olopatadine
- Rupatadine
- Mepolizumab
- Omalizumab
- Pemirolast
- Quercetin
- Nedocromil
- Azelastine
- Tranilast
- Palmitoylethanolamide
- Vitamin D[3]
gollark: ```For instance, say I want a wooden chest: I've got several solutions: - Use an existing chest- Craft a chest from existing planks - Craft planks and then craft a chest Now, normally I'd say the first is the best. But what happens if I've only got 1 dark oak chests, and I've got 1000 oak planks. Surely it'd be better to create a chest from the planks in this case, as it results in a more balanced system.```Mentioned by the people on the CC discord I asked.
gollark: And no good way to tell which one is "best".
gollark: Well, there are multiple patterns for most items, see.
gollark: How to generate the list of crafting tasks and their order.
gollark: That bit is easy.
References
- "Allergy medications: Know your options". Mayoclinic.com. 2017-06-06. Retrieved 2018-05-24.
- Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis". Cochrane Database Syst Rev. 6 (6): CD009566. doi:10.1002/14651858.CD009566.pub2. hdl:2164/6048. PMID 26028608.CS1 maint: uses authors parameter (link)
- Lui, ZQ; Lii, XX; Qui, ZQ; Yu, Y; Li, MG (2017). "Vitamin D contributes to mast cell stabilization". Allergy. 72 (8): 1184–1192. doi:10.1111/all.13110. PMID 27998003.
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