NCAPG2

Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene.[5][6] CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis[7]

NCAPG2
Identifiers
Aliases	NCAPG2, CAP-G2, CAPG2, LUZP5, MTB, hCAP-G2, non-SMC condensin II complex subunit G2, 3KS
External IDs	OMIM: 608532 MGI: 1923294 HomoloGene: 9820 GeneCards: NCAPG2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.3 Start 158,631,169 bp[1] End 158,704,804 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F2 Start 116,405,402 bp[2] End 116,463,731 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methylated histone binding • GO:0001948 protein binding • bHLH transcription factor binding • molecular function regulator Cellular component • membrane • cell nucleus • nucleoplasm • condensin complex • nuclear speck Biological process • cell division • cell cycle • chromosome condensation • inner cell mass cell proliferation • transcription from RNA polymerase II promoter • erythrocyte differentiation • negative regulation of erythrocyte differentiation • positive regulation of protein tyrosine kinase activity • positive regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54892	76044
Ensembl	ENSG00000146918	ENSMUSG00000042029
UniProt	Q86XI2	Q6DFV1
RefSeq (mRNA)	NM_001281932 NM_001281933 NM_017760	NM_133762
RefSeq (protein)	NP_001268861 NP_001268862 NP_060230	NP_598523
Location (UCSC)	Chr 7: 158.63 – 158.7 Mb	Chr 12: 116.41 – 116.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical importance

Mutations in this gene in humans have been associated with severe neurodevelopmental defects, failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000146918 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042029 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T (October 2003). "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells". Cell. 115 (1): 109–21. doi:10.1016/S0092-8674(03)00724-4. PMID 14532007.
6. "Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2".
7. Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT (August 2014). "The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores". Nature Communications. 5: 4588. Bibcode:2014NatCo...5.4588K. doi:10.1038/ncomms5588. PMID 25109385.
8. Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM, Davis EE, Katsanis N, et al. (Task Force for Neonatal Genomics) (January 2019). "Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies". American Journal of Human Genetics. 104 (1): 94–111. doi:10.1016/j.ajhg.2018.11.017. PMC 6323578. PMID 30609410.

Further reading

• Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD (February 2004). "More than blood, a novel gene required for mammalian postimplantation development". Molecular and Cellular Biology. 24 (3): 1168–73. doi:10.1128/MCB.24.3.1168-1173.2004. PMC 321451. PMID 14729962.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.