Nucleoporin 54

Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene.[5][6]

NUP54
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JNU, 4JNV, 4JO7, 4JO9, 5IJO, 5IJN
Identifiers
Aliases	NUP54, nucleoporin 54
External IDs	OMIM: 607607 MGI: 1920460 HomoloGene: 41169 GeneCards: NUP54
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 76,114,659 bp[1] End 76,148,444 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 92,415,540 bp[2] End 92,435,219 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • GO:0005487 structural constituent of nuclear pore Cellular component • nuclear membrane • nuclear envelope • membrane • nuclear pore • nuclear pore central transport channel • cell nucleus • macromolecular complex • host cell Biological process • protein targeting • mRNA transport • protein heterotetramerization • protein localization to nuclear inner membrane • protein heterooligomerization • nucleocytoplasmic transport • regulation of protein import into nucleus • protein transport • GO:0022415 viral process • protein homooligomerization • nuclear pore organization • NLS-bearing protein import into nucleus • mRNA export from nucleus • protein heterotrimerization • regulation of glycolytic process • tRNA export from nucleus • protein sumoylation • viral transcription • regulation of gene silencing by miRNA • GO:0046795 intracellular transport of virus • regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53371	269113
Ensembl	ENSG00000138750	ENSMUSG00000034826
UniProt	Q7Z3B4	Q8BTS4
RefSeq (mRNA)	NM_001278603 NM_017426	NM_183392 NM_001359995
RefSeq (protein)	NP_001265532 NP_059122	NP_899248 NP_001346924
Location (UCSC)	Chr 4: 76.11 – 76.15 Mb	Chr 5: 92.42 – 92.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138750 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034826 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hu T, Guan T, Gerace L (Sep 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
6. "Entrez Gene: NUP54 nucleoporin 54kDa".

Further reading

• Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.
• Bodoor K, Shaikh S, Enarson P, Chowdhury S, Salina D, Raharjo WH, Burke B (1999). "Function and assembly of nuclear pore complex proteins". Biochem. Cell Biol. 77 (4): 321–329. doi:10.1139/bcb-77-4-321. PMID 10546895.
• Finlay DR, Meier E, Bradley P, Horecka J, Forbes DJ (1991). "A complex of nuclear pore proteins required for pore function". J. Cell Biol. 114 (1): 169–183. doi:10.1083/jcb.114.1.169. PMC 2289063. PMID 2050741.
• Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–261. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Guan T, Müller S, Klier G, Panté N, Blevitt JM, Haner M, Paschal B, Aebi U, Gerace L (1996). "Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex". Mol. Biol. Cell. 6 (11): 1591–1603. doi:10.1091/mbc.6.11.1591. PMC 301313. PMID 8589458.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Popov S, Rexach M, Ratner L, Blobel G, Bukrinsky M (1998). "Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex". J. Biol. Chem. 273 (21): 13347–13352. doi:10.1074/jbc.273.21.13347. PMID 9582382.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nucleoporin p54