Nucleoporin 160

Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene.[5][6]

NUP160
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A9Q
Identifiers
Aliases	NUP160, nucleoporin 160, Nup160, 160kDa, 2810011M03Rik, AA414952, AU020188, Gtl-13, Gtl1-13, Gtl13, mKIAA0197, NPHS19
External IDs	OMIM: 607614 MGI: 1926227 HomoloGene: 32509 GeneCards: NUP160
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 47,778,087 bp[1] End 47,848,555 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 90,677,215 bp[2] End 90,736,328 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • GO:0005487 structural constituent of nuclear pore Cellular component • cytosol • nuclear envelope • nuclear pore • nuclear pore outer ring • cell nucleus • kinetochore • host cell Biological process • mRNA transport • protein transport • GO:0022415 viral process • mRNA export from nucleus • regulation of glycolytic process • tRNA export from nucleus • protein sumoylation • viral transcription • regulation of gene silencing by miRNA • nephron development • GO:0046795 intracellular transport of virus • regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23279	59015
Ensembl	ENSG00000030066	ENSMUSG00000051329
UniProt	Q12769	Q9Z0W3
RefSeq (mRNA)	NM_015231 NM_001318399	NM_021512
RefSeq (protein)	NP_001305328 NP_056046	NP_067487
Location (UCSC)	Chr 11: 47.78 – 47.85 Mb	Chr 2: 90.68 – 90.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000030066 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051329 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (Oct 2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". J Cell Biol. 155 (3): 339–54. doi:10.1083/jcb.200108007. PMC 2150853. PMID 11684705.
6. "Entrez Gene: NUP160 nucleoporin 160kDa".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
• Belgareh N, Rabut G, Baï SW, et al. (2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". J. Cell Biol. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Mol. Biol. Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Orjalo AV, Arnaoutov A, Shen Z, et al. (2006). "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly". Mol. Biol. Cell. 17 (9): 3806–18. doi:10.1091/mbc.E05-11-1061. PMC 1593160. PMID 16807356.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Glavy JS, Krutchinsky AN, Cristea IM, et al. (2007). "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3811–6. doi:10.1073/pnas.0700058104. PMC 1820666. PMID 17360435.
• Zuccolo M, Alves A, Galy V, et al. (2007). "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions". EMBO J. 26 (7): 1853–64. doi:10.1038/sj.emboj.7601642. PMC 1847668. PMID 17363900.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear pore complex protein Nup160