Gem-associated protein 7

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.[5][6]The gem-associated proteins are those found in the gems of Cajal bodies.

GEMIN7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y96
Identifiers
Aliases	GEMIN7, SIP3, gem nuclear organelle associated protein 7
External IDs	OMIM: 607419 MGI: 1916981 HomoloGene: 11668 GeneCards: GEMIN7
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,079,195 bp[1] End 45,091,518 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 19,564,946 bp[2] End 19,577,595 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • nuclear body • cell nucleus • nucleoplasm • SMN complex • SMN-Sm protein complex • Gemini of coiled bodies Biological process • mRNA splicing, via spliceosome • mRNA processing • RNA splicing • spliceosomal snRNP assembly • nuclear import Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79760	69731
Ensembl	ENSG00000142252	ENSMUSG00000044709
UniProt	Q9H840	Q9CWY4
RefSeq (mRNA)	NM_001007269 NM_001007270 NM_024707 NM_001319054 NM_001319055	NM_027189
RefSeq (protein)	NP_001007270 NP_001007271 NP_001305983 NP_001305984 NP_078983	NP_081465
Location (UCSC)	Chr 19: 45.08 – 45.09 Mb	Chr 7: 19.56 – 19.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[6]

Interactions

Gem-associated protein 7 has been shown to interact with SMN1[5][7] and Gem-associated protein 6.[5] [8]

References

1. GRCh38: Ensembl release 89: ENSG00000142252 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044709 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–31962. doi:10.1074/jbc.M203478200. PMID 12065586.
6. "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7".
7. Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–7545. doi:10.1074/jbc.M110141200. PMID 11748230.
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–37016. doi:10.1074/jbc.M607505200. PMID 17023415.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U (Oct 2005). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization". Human Molecular Genetics. 14 (20): 3099–3111. doi:10.1093/hmg/ddi343. PMID 16159890.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Gem-associated protein 7