Gem-associated protein 7
Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.[5][6]The gem-associated proteins are those found in the gems of Cajal bodies.
Function
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[6]
Interactions
Gem-associated protein 7 has been shown to interact with SMN1[5][7] and Gem-associated protein 6.[5] [8]
gollark: `LOAD`/`STOR` can be made overly multipurpose by accepting a register to load the address from as well as a constant.
gollark: I just had an idea for using the spare space!
gollark: It does not wrap around. You are invoking undefined behaviot.
gollark: I'm being indecisive about whether I should just keep the existing instruction format and just leave some bits unused in `STOR/LOAD`/hopefully find something to do with them, or switch out `ADDI` and use the spare space to make instructions excessively conditional.
gollark: So reassigning yet another register to hold a bunch of flags or something, splitting ADDI back into multiple instructions, and using the extra space for conditionals could work.
References
- GRCh38: Ensembl release 89: ENSG00000142252 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000044709 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–31962. doi:10.1074/jbc.M203478200. PMID 12065586.
- "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7".
- Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–7545. doi:10.1074/jbc.M110141200. PMID 11748230.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–37016. doi:10.1074/jbc.M607505200. PMID 17023415.
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
- Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U (Oct 2005). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization". Human Molecular Genetics. 14 (20): 3099–3111. doi:10.1093/hmg/ddi343. PMID 16159890.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Gem-associated protein 7
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