Nucleoporin 35

Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene.[4]

NUP35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LIR
Identifiers
Aliases	NUP35, MP-44, MP44, NP44, NUP53, nucleoporin 35kDa, nucleoporin 35
External IDs	OMIM: 608140 MGI: 1916732 HomoloGene: 44517 GeneCards: NUP35
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.1 Start 183,117,513 bp[1] End 183,161,680 bp[1]
Gene ontology Molecular function • single-stranded DNA binding • GO:0001948 protein binding • phospholipid binding • nucleic acid binding • GO:0005487 structural constituent of nuclear pore Cellular component • nuclear lamina • nuclear membrane • nuclear envelope • membrane • cell membrane • nuclear pore • nucleoplasm • nuclear pore central transport channel • nuclear pore nuclear basket • cell nucleus • host cell Biological process • mRNA transport • regulation of transcription, DNA-templated • protein transport • GO:0022415 viral process • nuclear pore organization • NLS-bearing protein import into nucleus • mRNA export from nucleus • nucleocytoplasmic transport • regulation of glycolytic process • tRNA export from nucleus • protein sumoylation • viral transcription • regulation of gene silencing by miRNA • GO:0046795 intracellular transport of virus • regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	129401	69482
Ensembl	ENSG00000163002	n/a
UniProt	Q8NFH5	Q8R4R6
RefSeq (mRNA)	NM_001008544 NM_001287584 NM_001287585 NM_138285	NM_001190179 NM_027091
RefSeq (protein)	NP_001274513 NP_001274514 NP_612142	NP_001177108 NP_081367
Location (UCSC)	Chr 2: 183.12 – 183.16 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Background

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000163002 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: NUP35 nucleoporin 35kDa".

Further reading

• Rodenas E, Klerkx EP, Ayuso C, Audhya A, Askjaer P (2009). "Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly". Developmental Biology. 327 (2): 399–409. doi:10.1016/j.ydbio.2008.12.024. hdl:10261/17735. PMID 19146848.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells". Mol. Cell. 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup93-containing Complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cronshaw JM, Krutchinsky AN, Zhang W, et al. (2002). "Proteomic analysis of the mammalian nuclear pore complex". J. Cell Biol. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8NFH5 (Human Nucleoporin NUP35) at the PDBe-KB.