Gem-associated protein 5

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.[5][6]

GEMIN5
Identifiers
Aliases	GEMIN5, GEMIN-5, gem nuclear organelle associated protein 5
External IDs	OMIM: 607005 MGI: 2449311 HomoloGene: 9155 GeneCards: GEMIN5
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.2 Start 154,887,411 bp[1] End 154,938,211 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 58,120,002 bp[2] End 58,168,539 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • snRNA binding • GO:0001948 protein binding • RNA 7-methylguanosine cap binding • mRNA 3'-UTR binding • U1 snRNA binding • U4 snRNA binding • U4atac snRNA binding • ribosome binding • RNA binding Cellular component • cytoplasm • SMN complex • SMN-Sm protein complex • cytosol • nuclear body • membrane • Gemini of coiled bodies • nucleoplasm • cell nucleus • cytosolic large ribosomal subunit • SMN-Gemin2 complex Biological process • mRNA splicing, via spliceosome • mRNA processing • RNA splicing • spliceosomal snRNP assembly • nuclear import • protein biosynthesis • regulation of translation • macromolecular complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25929	216766
Ensembl	ENSG00000082516	ENSMUSG00000037275
UniProt	Q8TEQ6	Q8BX17
RefSeq (mRNA)	NM_015465 NM_001252156	NM_001166669 NM_001166670 NM_001166671 NM_172558 NM_001374702
RefSeq (protein)	NP_001239085 NP_056280	NP_001160141 NP_001160142 NP_001160143 NP_766146 NP_001361631
Location (UCSC)	Chr 5: 154.89 – 154.94 Mb	Chr 11: 58.12 – 58.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Gem-associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[6]

Interactions

GEMIN5 has been shown to interact with DDX20[5][7] and SMN1.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000082516 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037275 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
6. "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5".
7. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.

Further reading

• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Battle DJ, Lau CK, Wan L, Deng H, Lotti F, Dreyfuss G (2006). "The Gemin5 protein of the SMN complex identifies snRNAs". Mol. Cell. 23 (2): 273–9. doi:10.1016/j.molcel.2006.05.036. PMID 16857593.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Kim EK, Noh KT, Yoon JH, Cho JH, Yoon KW, Dreyfuss G, Choi EJ (2007). "Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5". Cell Death Differ. 14 (8): 1518–28. doi:10.1038/sj.cdd.4402157. PMID 17541429.
• Hao le T, Fuller HR, Lam le T, Le TT, Burghes AH, Morris GE (2007). "Absence of gemin5 from SMN complexes in nuclear Cajal bodies". BMC Cell Biol. 8: 28. doi:10.1186/1471-2121-8-28. PMC 1939999. PMID 17640370.
• Battle DJ, Kasim M, Wang J, Dreyfuss G (2007). "SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate". J. Biol. Chem. 282 (38): 27953–9. doi:10.1074/jbc.M702317200. PMID 17640873.