Mannosylglycerate hydrolase

Mannosylglycerate hydrolase (EC 3.2.1.170, 2-O-(6-phospho-mannosyl)-D-glycerate hydrolase, alpha-mannosidase, mngB (gene)) is an enzyme with systematic name 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate acylhydrolase.[1] This enzyme catalyses the following chemical reaction

2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H2O D-mannose 6-phosphate + D-glycerate
Mannosylglycerate hydrolase
Identifiers
EC number3.2.1.170
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme participates in the mannosylglycerate degradation pathway of some bacteria.

References

  1. Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO (February 2004). "Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor". The Journal of Biological Chemistry. 279 (7): 5537–48. doi:10.1074/jbc.m310980200. PMID 14645248.
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