Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113, mannosidase 1A, mannosidase 1B, 1,2-alpha-mannosidase, exo-alpha-1,2-mannanase, mannose-9 processing alpha-mannosidase, glycoprotein processing mannosidase I, mannosidase I, Man9-mannosidase, ManI, 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase) is an enzyme with systematic name 2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase.[1][2] This enzyme catalyses the following chemical reaction
- Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2
| Mannosyl-oligosaccharide 1,2-alpha-mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.113 | ||||||||
| CAS number | 9068-25-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is involved in the synthesis of glycoproteins.
Kifunensine is a potent inhibitor of mannosidase I.
References
- Tabas I, Kornfeld S (November 1979). "Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides". The Journal of Biological Chemistry. 254 (22): 11655–63. PMID 500665.
- Tulsiani DR, Hubbard SC, Robbins PW, Touster O (April 1982). "alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry. 257 (7): 3660–8. PMID 7061502.
External links
- Mannosyl-oligosaccharide+1,2-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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