Gellan tetrasaccharide unsaturated glucuronyl hydrolase
Gellan tetrasaccharide unsaturated glucuronyl hydrolase (EC 3.2.1.179, UGL, unsaturated glucuronyl hydrolase) is an enzyme with systematic name beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp beta-D-4-deoxy-Delta4-GlcAp hydrolase.[1][2][3] This enzyme catalyses the following chemical reaction
- beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp + H2O 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp
| Gellan tetrasaccharide unsaturated glucuronyl hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.179 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme releases 4-deoxy-4(5)-unsaturated D-glucuronic acid from oligosaccharides produced by polysaccharide lyases.
References
- Itoh T, Akao S, Hashimoto W, Mikami B, Murata K (July 2004). "Crystal structure of unsaturated glucuronyl hydrolase, responsible for the degradation of glycosaminoglycan, from Bacillus sp. GL1 at 1.8 A resolution". The Journal of Biological Chemistry. 279 (30): 31804–12. doi:10.1074/jbc.m403288200. PMID 15148314.
- Hashimoto W, Kobayashi E, Nankai H, Sato N, Miya T, Kawai S, Murata K (August 1999). "Unsaturated glucuronyl hydrolase of Bacillus sp. GL1: novel enzyme prerequisite for metabolism of unsaturated oligosaccharides produced by polysaccharide lyases". Archives of Biochemistry and Biophysics. 368 (2): 367–74. doi:10.1006/abbi.1999.1305. PMID 10441389.
- Itoh T, Hashimoto W, Mikami B, Murata K (May 2006). "Substrate recognition by unsaturated glucuronyl hydrolase from Bacillus sp. GL1". Biochemical and Biophysical Research Communications. 344 (1): 253–62. doi:10.1016/j.bbrc.2006.03.141. PMID 16630576.
External links
- Gellan+tetrasaccharide+unsaturated+glucuronyl+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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