Endoglycosylceramidase
In enzymology, an endoglycosylceramidase (EC 3.2.1.123) is an enzyme that catalyzes the chemical reaction
- oligoglycosylglucosylceramide + H2O ceramide + oligoglycosylglucose
| endoglycosylceramidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.123 | ||||||||
| CAS number | 105503-61-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are oligoglycosylglucosylceramide and H2O, whereas its two products are ceramide and oligoglycosylglucose.
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is oligoglycosylglucosylceramide glycohydrolase. Other names in common use include endoglycoceramidase, EGCase, and glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2OSW, 2OSX, 2OSY, 2OYK, 2OYL, and 2OYM.
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References
- Ito M, Yamagata T (1986). "A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids". J. Biol. Chem. 261 (30): 14278–82. PMID 3771534.
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