Endo-alpha-sialidase

Endo-alpha-sialidase (EC 3.2.1.129, endo-N-acylneuraminidase, endoneuraminidase, endo-N-acetylneuraminidase, poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase, poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase, endosialidase, endo-N) is an enzyme with systematic name polysialoside (2->8)-alpha-sialosylhydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction:

Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids
Endo-alpha-sialidase
Identifiers
EC number3.2.1.129
CAS number91195-87-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

References

  1. Finne J, Mäkelä PH (January 1985). "Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid". The Journal of Biological Chemistry. 260 (2): 1265–70. PMID 3968060.
  2. Hallenbeck PC, Vimr ER, Yu F, Bassler B, Troy FA (March 1987). "Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-alpha-2,8-sialosyl carbohydrate units". The Journal of Biological Chemistry. 262 (8): 3553–61. PMID 3546309.
  3. Kitajima K, Inoue S, Inoue Y, Troy FA (December 1988). "Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies". The Journal of Biological Chemistry. 263 (34): 18269–76. PMID 3142874.
  4. Kwiatkowski B, Boschek B, Thiele H, Stirm S (August 1982). "Endo-N-acetylneuraminidase associated with bacteriophage particles". Journal of Virology. 43 (2): 697–704. PMC 256172. PMID 7109038.
  5. Pelkonen S, Pelkonen J, Finne J (October 1989). "Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins". Journal of Virology. 63 (10): 4409–16. PMC 251059. PMID 2778882.
  6. Tomlinson S, Taylor PW (August 1985). "Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide". Journal of Virology. 55 (2): 374–8. PMC 254943. PMID 3894684.
  7. Cabezas JA (August 1991). "Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase". The Biochemical Journal. 278 ( Pt 1): 311–2. doi:10.1042/bj2780311. PMC 1151486. PMID 1883340.


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