Dipeptidase 3

Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.[5]

DPEP3
Identifiers
Aliases	DPEP3, MBD3, dipeptidase 3
External IDs	OMIM: 609926 MGI: 1919104 HomoloGene: 23357 GeneCards: DPEP3
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,975,663 bp[1] End 67,980,549 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 105,973,513 bp[2] End 105,979,429 bp[2]
Gene ontology Molecular function • peptidase activity • metalloexopeptidase activity • dipeptidyl-peptidase activity • metallopeptidase activity • hydrolase activity • metal ion binding • dipeptidase activity Cellular component • anchored component of membrane • membrane • Acrosome • cell membrane Biological process • male meiotic nuclear division • GO:0007126 meiotic cell cycle • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64180	71854
Ensembl	ENSG00000141096	ENSMUSG00000031898
UniProt	Q9H4B8	Q9DA79
RefSeq (mRNA)	NM_022357 NM_001129758 NM_001370198	NM_027960
RefSeq (protein)	NP_001123230 NP_001357127	NP_082236
Location (UCSC)	Chr 16: 67.98 – 67.98 Mb	Chr 8: 105.97 – 105.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a membrane-bound glycoprotein from the family of dipeptidases (EC 3.4.13.19) involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family, DPEP2. Alternatively spliced transcript variants that encode different isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000141096 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031898 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (July 2003). "Identification of two additional members of the membrane-bound dipeptidase family". The FASEB Journal. 17 (10): 1313–5. doi:10.1096/fj.02-0899fje. PMID 12738806.
6. "Entrez Gene: Dipeptidase 3".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sabatti C, Service SK, Hartikainen AL, et al. (2009). "Genome-wide association analysis of metabolic traits in a birth cohort from a founder population". Nat. Genet. 41 (1): 35–46. doi:10.1038/ng.271. PMC 2687077. PMID 19060910.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.