DNA-3-methyladenine glycosylase I
DNA-3-methyladenine glycosylase I (EC 3.2.2.20, deoxyribonucleate 3-methyladenine glycosidase I, 3-methyladenine DNA glycosylase I, DNA-3-methyladenine glycosidase I) is an enzyme with systematic name alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine).[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of alkylated DNA, releasing 3-methyladenine
| DNA-3-methyladenine glycosylase I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.2.20 | ||||||||
| CAS number | 89287-37-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is involved in the removal of alkylated bases from DNA in Escherichia coli.
References
- Evensen G, Seeberg E (April 1982). "Adaptation to alkylation resistance involves the induction of a DNA glycosylase". Nature. 296 (5859): 773–5. doi:10.1038/296773a0. PMID 7040984.
- Karran P, Hjelmgren T, Lindahl T (April 1982). "Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents". Nature. 296 (5859): 770–3. doi:10.1038/296770a0. PMID 7040983.
- Thomas L, Yang CH, Goldthwait DA (March 1982). "Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine". Biochemistry. 21 (6): 1162–9. doi:10.1021/bi00535a009. PMID 7041972.
External links
- DNA-3-methyladenine+glycosylase+I at the US National Library of Medicine Medical Subject Headings (MeSH)
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