Ammonium sulfate

Ammonium sulfate (American English and international scientific usage; ammonium sulphate in British English); (NH₄)₂SO₄, is an inorganic salt with a number of commercial uses. The most common use is as a soil fertilizer. It contains 21% nitrogen and 24% sulfur.

Ammonium sulfate

Names
IUPAC name Ammonium tetraoxosulfate (VI)
Other names Ammonium sulphate Ammonium sulfate (2:1) Diammonium sulfate Sulfuric acid diammonium salt Mascagnite Actamaster Dolamin
Identifiers
CAS Number	7783-20-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:62946
ChemSpider	22944^Y
ECHA InfoCard	100.029.076
EC Number	231-984-1
E number	E517 (acidity regulators, ...)
KEGG	D08853^Y
PubChem CID	6097028
UNII	SU46BAM238^Y
CompTox Dashboard (EPA)	DTXSID1029704
InChI InChI=1S/2H3N.H2O4S/c;;1-5(2,3)4/h2*1H3;(H2,1,2,3,4)^Y Key: BFNBIHQBYMNNAN-UHFFFAOYSA-N^Y InChI=1/2H3N.H2O4S/c;;1-5(2,3)4/h2*1H3;(H2,1,2,3,4) Key: BFNBIHQBYMNNAN-UHFFFAOYAI
SMILES O=S(=O)(O)O.N.N
Properties
Chemical formula	(NH4)2SO4
Molar mass	132.14 g/mol
Appearance	Fine white hygroscopic granules or crystals
Density	1.77 g/cm^3
Melting point	235 to 280 °C (455 to 536 °F; 508 to 553 K) (decomposes)
Solubility in water	70.6 g per 100 g water (0 °C) 74.4 g per 100 g water (20 °C) 103.8 g per 100 g water (100 °C)[1]
Solubility	Insoluble in acetone, alcohol and ether
Magnetic susceptibility (χ)	-67.0·10^−6 cm^3/mol
Critical relative humidity	79.2% (30 °C)
Hazards
GHS pictograms
GHS Signal word	Warning
GHS hazard statements	H315, H319, H335
GHS precautionary statements	P261, P264, P270, P271, P273, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362, P391, P403+233, P405, P501
NFPA 704 (fire diamond)	1 2 0
Flash point	Non-flammable
Lethal dose or concentration (LD, LC):
LD50 (median dose)	2840 mg/kg, rat (oral)
Related compounds
Other anions	Ammonium thiosulfate Ammonium sulfite Ammonium bisulfate Ammonium persulfate
Other cations	Sodium sulfate Potassium sulfate
Related compounds	Ammonium iron(II) sulfate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is ^YN ?)
Infobox references

Uses

The primary use of ammonium sulfate is as a fertilizer for alkaline soils. In the soil the ammonium ion is released and forms a small amount of acid, lowering the pH balance of the soil, while contributing essential nitrogen for plant growth. The main disadvantage to the use of ammonium sulfate is its low nitrogen content relative to ammonium nitrate, which elevates transportation costs.[2]

It is also used as an agricultural spray adjuvant for water-soluble insecticides, herbicides, and fungicides. There, it functions to bind iron and calcium cations that are present in both well water and plant cells. It is particularly effective as an adjuvant for 2,4-D (amine), glyphosate, and glufosinate herbicides.

Laboratory use

Ammonium sulfate precipitation is a common method for protein purification by precipitation. As the ionic strength of a solution increases, the solubility of proteins in that solution decreases. Ammonium sulfate is extremely soluble in water due to its ionic nature, therefore it can "salt out" proteins by precipitation.[3] Due to the high dielectric constant of water, the dissociated salt ions being cationic ammonium and anionic sulfate are readily solvated within hydration shells of water molecules. The significance of this substance in the purification of compounds stems from its ability to become more so hydrated compared to relatively more nonpolar molecules and so the desirable non-polar molecules coalesce and precipitate out of the solution in a concentrated form. This method is called salting out and necessitates the use of high salt concentrations that can reliably dissolve in the aqueous mixture. The percentage of the salt used is in comparison to the maximal concentration of the salt in the mixture can dissolve. As such, although high concentrations are needed for the method to work adding an abundance of the salt, over 100%, can also oversaturate the solution, therefore, contaminating the non-polar precipitate with salt precipitate.[4] A high salt concentration, which can be achieved by adding or increasing the concentration of ammonium sulfate in a solution, enables protein separation based on a decrease in protein solubility; this separation may be achieved by centrifugation. Precipitation by ammonium sulfate is a result of a reduction in solubility rather than protein denaturation, thus the precipitated protein can be solubilized through the use of standard buffers.[5] Ammonium sulfate precipitation provides a convenient and simple means to fractionate complex protein mixtures.[6]

In the analysis of rubber lattices, volatile fatty acids are analyzed by precipitating rubber with a 35% ammonium sulfate solution, which leaves a clear liquid from which volatile fatty acids are regenerated with sulfuric acid and then distilled with steam. Selective precipitation with ammonium sulfate, opposite to the usual precipitation technique which uses acetic acid, does not interfere with the determination of volatile fatty acids.[7]

Food additive

As a food additive, ammonium sulfate is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration,[8] and in the European Union it is designated by the E number E517. It is used as an acidity regulator in flours and breads.[9][10][11]

Other uses

In the treatment of drinking water, ammonium sulfate is used in combination with chlorine to generate monochloramine for disinfection.[12]

Ammonium sulfate is used on a small scale in the preparation of other ammonium salts, especially ammonium persulfate.

Ammonium sulfate is listed as an ingredient for many United States vaccines per the Center for Disease Control.[13]

A saturated solution of ammonium sulfate in heavy water (D₂O) is used as an external standard in sulfur (³³S) NMR spectroscopy with shift value of 0 ppm.

Ammonium sulfate has also been used in flame retardant compositions acting much like diammonium phosphate. As a flame retardant, it increases the combustion temperature of the material, decreases maximum weight loss rates, and causes an increase in the production of residue or char.[14] Its flame retardant efficacy can be enhanced by blending it with ammonium sulfamate. It has been used in aerial firefighting.

Ammonium sulfate has been used as a wood preservative, but due to its hygroscopic nature, this use has been largely discontinued because of associated problems with metal fastener corrosion, dimensional instability, and finish failures.

Preparation

Ammonium sulfate is made by treating ammonia, often as a by-product from coke ovens, with sulfuric acid:

2 NH₃ + H₂SO₄ → (NH₄)₂SO₄

A mixture of ammonia gas and water vapor is introduced into a reactor that contains a saturated solution of ammonium sulfate and about 2 to 4% of free sulfuric acid at 60 °C. Concentrated sulfuric acid is added to keep the solution acidic, and to retain its level of free acid. The heat of reaction keeps reactor temperature at 60 °C. Dry, powdered ammonium sulfate may be formed by spraying sulfuric acid into a reaction chamber filled with ammonia gas. The heat of reaction evaporates all water present in the system, forming a powdery salt. Approximately 6000M tons were produced in 1981.[2]

Ammonium sulfate also is manufactured from gypsum (CaSO₄·2H₂O). Finely divided gypsum is added to an ammonium carbonate solution. Calcium carbonate precipitates as a solid, leaving ammonium sulfate in the solution.

(NH₄)₂CO₃ + CaSO₄ → (NH₄)₂SO₄ + CaCO₃

Ammonium sulfate occurs naturally as the rare mineral mascagnite in volcanic fumaroles and due to coal fires on some dumps.[15]

Properties

Ammonium sulfate becomes ferroelectric at temperatures below -49.5 °C. At room temperature it crystallises in the orthorhombic system, with cell sizes of a = 7.729 Å, b = 10.560 Å, c = 5.951 Å. When chilled into the ferrorelectric state, the symmetry of the crystal changes to space group Pna2₁.[16]

Reactions

Ammonium sulfate decomposes upon heating above 250 °C, first forming ammonium bisulfate. Heating at higher temperatures results in decomposition into ammonia, nitrogen, sulfur dioxide, and water.[17]

As a salt of a strong acid (H₂SO₄) and weak base (NH₃), its solution is acidic; pH of 0.1 M solution is 5.5. In aqueous solution the reactions are those of NH₄⁺ and SO₄⁻² ions. For example, addition of barium chloride, precipitates out barium sulfate. The filtrate on evaporation yields ammonium chloride.

Ammonium sulfate forms many double salts (ammonium metal sulfates) when its solution is mixed with equimolar solutions of metal sulfates and the solution is slowly evaporated. With trivalent metal ions, alums such as ferric ammonium sulfate are formed. Double metal sulfates include ammonium cobaltous sulfate, ferrous diammonium sulfate, ammonium nickel sulfate which are known as Tutton's salts and ammonium ceric sulfate.[2] Anhydrous double sulfates of ammonium also occur in the Langbeinites family.

Airborne particles of evaporated ammonium sulfate comprise approximately 30% of fine particulate pollution worldwide.[18]

Legislation and control

In November 2009, a ban on ammonium sulfate, ammonium nitrate and calcium ammonium nitrate fertilizers was imposed in the former Malakand Division—comprising the Upper Dir, Lower Dir, Swat, Chitral and Malakand districts of the North West Frontier Province (NWFP) of Pakistan, by the NWFP government, following reports that they were used by militants to make explosives. In January 2010, these substances were also banned in Afghanistan for the same reason.[19]

See also

• Ammonium sulfate precipitation

References

1. Lide, David R., ed. (2006). CRC Handbook of Chemistry and Physics (87th ed.). Boca Raton, FL: CRC Press. ISBN 0-8493-0487-3.
2. Karl-Heinz Zapp "Ammonium Compounds" in Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim. doi:10.1002/14356007.a02_243
3. Duong-Ly, Krisna C.; Gabelli, Sandra B. (2014-01-01). "Salting out of Proteins Using Ammonium Sulfate Precipitation". In Lorsch, Jon (ed.). Methods in Enzymology. Laboratory Methods in Enzymology: Protein Part C. 541. Academic Press. pp. 85–94. doi:10.1016/B978-0-12-420119-4.00007-0. ISBN 9780124201194. PMID 24674064.
4. Duong-Ly, Krisna C.; Gabelli, Sandra B. (2014-01-01). "Salting out of proteins using ammonium sulfate precipitation". Methods in Enzymology. 541: 85–94. doi:10.1016/B978-0-12-420119-4.00007-0. ISBN 9780124201194. ISSN 1557-7988. PMID 24674064.
5. Wingfield, Paul T. (2017-05-05). "Protein Precipitation Using Ammonium Sulfate". Current Protocols in Protein Science. 13 (1): A.3F.1–8. doi:10.1002/0471140864.psa03fs13. ISBN 978-0471140863. ISSN 1934-3655. PMC 4817497. PMID 18429073.
6. "Ammonium Sulfate Calculator". EnCor Biotechnology Inc. 2013. Retrieved March 2, 2013.
7. ASTM Standard Specification for Rubber Concentrates D 1076-06
8. "Select Committee on GRAS Substances (SCOGS) Opinion: Ammonium sulfate". U.S. Food and Drug Administration. August 16, 2011. Retrieved March 2, 2013.
9. "Panera Bread › Menu & Nutrition › Nutrition Information Profile". Archived from the original on August 19, 2009. Retrieved March 2, 2013.
10. "Official Subway Restaurants U.S. Products Ingredients Guide". Archived from the original on August 14, 2011. Retrieved March 2, 2013.
11. Sarah Klein (May 14, 2012). "Gross Ingredients In Processed Foods". The Huffington Post. Retrieved March 2, 2013.
12. McCool, Pat. "Feeding Ammonium Sulfate to Form Combined Chlorine Residual" (PDF). The Kansas Lifeline. Kansas Rural Water Association. Retrieved 6 June 2019.
13. "Vaccine Excipient & Media Summary" (PDF). Centers for Disease Control and Prevention (CDC). February 2012. Retrieved March 2, 2013.
14. George, C. W.; Susott, R. A. (April 1971). "Effects of Ammonium Phosphate and Sulfate on the Pyrolysis and Combustion of Cellulose". Research Paper INT-90. Intermountain Forest and Range Experiment Station: USDA Forest Service.
15. "Mascagnite". Mindat. Retrieved March 2, 2013.
16. Okaya, Y.; K. Vedam; R. Pepinsky (1958). "Non-isomorphism of ferroelectric phases of ammonium sulfate and ammonium fluoberyllate". Acta Crystallographica. 11 (4): 307. doi:10.1107/s0365110x58000803. ISSN 0365-110X.
17. Liu Ke-wei, Chen Tian-lang (2002). "Studies on the thermal decomposition of ammonium sulfate". Chemical Research and Application (in Chinese). 14 (6). doi:10.3969/j.issn.1004-1656.2002.06.038.
18. "Where Does Air Pollution Come From?". www.purakamasks.com. 2019-02-15. Retrieved 2019-02-20.
19. "PAKISTAN: 'Anti-terrorist' fertilizer ban hinders farmers". IRIN Humanitarian News and Analysis. 2010. Retrieved April 24, 2013.

Further reading

• Properties: UNIDO and International Fertilizer Development Center (1998), Fertilizer Manual, Kluwer Academic Publishers, ISBN 0-7923-5032-4.

External links

• Ammonium sulfate in the Pesticide Properties DataBase (PPDB)
• Calculators: surface tensions, and densities, molarities and molalities of aqueous ammonium sulfate