Amedalin

Amedalin (UK-3540-1) is an antidepressant which was synthesized in the early 1970s, but was never marketed.[1][2] It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.[2][3]

Amedalin

Clinical data
ATC code	None
Identifiers
IUPAC name 3-Methyl-3-[3-(methylamino)propyl]-1-phenyl-1,3-dihydro-2H-indol-2-one
CAS Number	22136-26-1^Y 22232-73-1 (HCl)
PubChem CID	31075
ChemSpider	28832^Y
UNII	2OWK6X9N16
KEGG	D02891^N
ChEMBL	ChEMBL2110769^N
Chemical and physical data
Formula	C19H22N2O
Molar mass	294.398 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC1(C2=CC=CC=C2N(C1=O)C3=CC=CC=C3)CCCNC
InChI InChI=1S/C19H22N2O/c1-19(13-8-14-20-2)16-11-6-7-12-17(16)21(18(19)22)15-9-4-3-5-10-15/h3-7,9-12,20H,8,13-14H2,1-2H3^Y Key:HBGWAZBZXJBYQD-UHFFFAOYSA-N^Y
^NY (what is this?)  (verify)

See also

• Daledalin

References

1. Triggle DJ (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 978-0-412-46630-4.
2. Cañas-Rodriguez A, Leeming PR (July 1972). "N-Phenyl-2-indolinones and N-phenylindolines. A new class of antidepressant agents". Journal of Medicinal Chemistry. 15 (7): 762–70. doi:10.1021/jm00277a017. PMID 5043876.
3. Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". Journal of Pharmacology and Experimental Therapeutics. 199 (3): 649–661. PMID 994022.