Alpha-glucuronidase

In enzymology, an alpha-glucuronidase (EC 3.2.1.139) is an enzyme that catalyzes the chemical reaction

an alpha-D-glucuronoside + H2O an alcohol + D-glucuronate
alpha-glucuronidase
Identifiers
EC number3.2.1.139
CAS number37259-81-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

For beta-glucuronidase, see Beta-glucuronidase

Thus, the two substrates of this enzyme are alpha-D-glucuronoside and H2O, whereas its two products are alcohol and D-glucuronate.

This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-D-glucosiduronate glucuronohydrolase. This enzyme is also called alpha-glucosiduronase.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1GQI, 1GQJ, 1GQK, 1GQL, 1H41, 1K9D, 1K9E, 1K9F, 1L8N, 1MQP, 1MQQ, 1MQR, and 1VJT.

See also

References

    • Visser, J., Kusters van Someren, M.A., Beldman, G. and Voragen, A.G.J. (Eds.), Xylans and Xylanases, Elsevier, Amsterdam, 1992, p. 213-224.
    • Uchida H, Nanri T, Kawabata Y, Kusakabe I, Murakami K (1992). "Purification and characterization of intracellular alpha-glucuronidase from Aspergillus niger". Biosci. Biotechnol. Biochem. 56 (10): 1608–1615. doi:10.1271/bbb.56.1608.


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