Acetoacetyl-CoA hydrolase
In enzymology, an acetoacetyl-CoA hydrolase (EC 3.1.2.11) is an enzyme that catalyzes the chemical reaction
- acetoacetyl-CoA + H2O CoA + acetoacetate
| acetoacetyl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.2.11 | ||||||||
| CAS number | 37288-10-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acetoacetyl-CoA and H2O, whereas its two products are CoA and acetoacetate.
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acetoacetyl-CoA hydrolase. Other names in common use include acetoacetyl coenzyme A hydrolase, acetoacetyl CoA deacylase, and acetoacetyl coenzyme A deacylase. This enzyme participates in butanoate metabolism.
References
- Aragon JJ, Lowenstein JM (1983). "A survey of enzymes which generate or use acetoacetyl thioesters in rat liver". J. Biol. Chem. 258 (8): 4725–33. PMID 6131897.
- DRUMMOND GI, STERN JR (1960). "Enzymes of ketone body metabolism. II. Properties of an acetoacetate-synthesizing enzyme prepared from ox liver". J. Biol. Chem. 235: 318–25. PMID 13818236.
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