ADP-ribosylarginine hydrolase
(Protein ADP-ribosylarginine) hydrolase (EC 3.2.2.19, ADP-ribose-L-arginine cleavage enzyme, Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase, protein-omega-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase) is an enzyme with systematic name protein-Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O ADP-ribose + protein-L-arginine
- (2) Nomega-(ADP-D-ribosyl)-L-arginine + H2O ADP-ribose + L-arginine
| (Protein ADP-ribosylarginine) hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.2.19 | ||||||||
| CAS number | 98668-52-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme will remove ADP-ribose from arginine residues in ADP-ribosylated proteins.
See also
References
- Moss J, Jacobson MK, Stanley SJ (September 1985). "Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme". Proceedings of the National Academy of Sciences of the United States of America. 82 (17): 5603–7. doi:10.1073/pnas.82.17.5603. PMC 390599. PMID 2994036.
- Moss J, Stanley SJ, Nightingale MS, Murtagh JJ, Monaco L, Mishima K, Chen HC, Williamson KC, Tsai SC (May 1992). "Molecular and immunological characterization of ADP-ribosylarginine hydrolases". The Journal of Biological Chemistry. 267 (15): 10481–8. PMID 1375222.
- Konczalik P, Moss J (June 1999). "Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases". The Journal of Biological Chemistry. 274 (24): 16736–40. doi:10.1074/jbc.274.24.16736. PMID 10358013.
- Takada T, Iida K, Moss J (August 1993). "Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase". The Journal of Biological Chemistry. 268 (24): 17837–43. PMID 8349667.
- Ohno T, Tsuchiya M, Osago H, Hara N, Jidoi J, Shimoyama M (October 1995). "Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase". Analytical Biochemistry. 231 (1): 115–22. doi:10.1006/abio.1995.1510. PMID 8678289.
External links
- (protein+ADP-ribosylarginine)+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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