6-phospho-beta-glucosidase

In enzymology, a 6-phospho-beta-glucosidase (EC 3.2.1.86) is an enzyme that catalyzes the chemical reaction

6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H2O D-glucose + D-glucose 6-phosphate
6-phospho-beta-glucosidase
Identifiers
EC number3.2.1.86
CAS number37205-51-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 6-phospho-beta-D-glucosyl-(1,4)-D-glucose and H2O, whereas its two products are D-glucose and D-glucose 6-phosphate.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase. Other names in common use include phospho-beta-glucosidase A, phospho-beta-glucosidase, and phosphocellobiase. This enzyme participates in glycolysis / gluconeogenesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1S6Y.

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References
    • Palmer RE, Anderson RL (1972). "Cellobiose metabolism in Aerobacter aerogenes. 3. Cleavage of cellobiose monophosphate by a phospho- -glucosidase". J. Biol. Chem. 247 (11): 3420–3. PMID 4624114.


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