1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1,4-dihydroxy-2-naphthoyl-CoA hydrolase (EC 3.1.2.28) is an enzyme with systematic name 1,4-dihydroxy-2-naphthoyl-CoA hydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

1,4-dihydroxy-2-naphthoyl-CoA + H2O 1,4-dihydroxy-2-naphthoate + CoA
1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Identifiers
EC number3.1.2.28
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme participates in the biosynthesis of menaquinones, phylloquinone, and several plant pigments.

References

  1. Widhalm, J.R.; van Oostende, C.; Furt, F.; Basset, G.J. (2009). "A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1". Proc. Natl. Acad. Sci. USA. 106: 5599–5603. doi:10.1073/pnas.0900738106. PMC 2660889. PMID 19321747.
  2. Muller, W; Leistner, E (1976). "1,4-naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis". Phytochemistry. 15: 407–410. doi:10.1016/s0031-9422(00)86833-8.
  3. Eichinger D, Bacher A, Zenk MH, Eisenreich W (1999). "Quantitative assessment of metabolic flux by 13C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum". J. Am. Chem. Soc. 121: 7469–7475. doi:10.1021/ja990622o.
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