OR4E2

Olfactory receptor 4E2 is a protein that in humans is encoded by the OR4E2 gene.[5]

OR4E2
Identifiers
Aliases	OR4E2, OR14-42, olfactory receptor family 4 subfamily E member 2, olfactory receptor family 4 subfamily E member 2 (gene/pseudogene)
External IDs	MGI: 3031343 HomoloGene: 41378 GeneCards: OR4E2
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 21,653,835 bp[1] End 21,667,642 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C2 Start 52,442,990 bp[2] End 52,452,574 bp[2]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • transmembrane signaling receptor activity • signal transducer activity • copper ion binding • odorant binding Cellular component • membrane • cell membrane • integral component of membrane • integral component of plasma membrane Biological process • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • detection of chemical stimulus involved in sensory perception • signal transduction • response to stimulus • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26686	57271
Ensembl	ENSG00000221977	ENSMUSG00000035626
UniProt	Q8NGC2	Q7TQQ0
RefSeq (mRNA)	NM_001001912	NM_020514
RefSeq (protein)	NP_001001912 NP_001001912	NP_065260
Location (UCSC)	Chr 14: 21.65 – 21.67 Mb	Chr 14: 52.44 – 52.45 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000221977 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035626 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4E2 olfactory receptor, family 4, subfamily E, member 2".

Further reading

• Koop BF, Rowen L, Wang K, et al. (1994). "The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA". Genomics. 19 (3): 478–93. doi:10.1006/geno.1994.1097. PMID 8188290.
• Boysen C, Simon MI, Hood L (1997). "Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones". Genome Res. 7 (4): 330–8. doi:10.1101/gr.7.4.330. PMID 9110172.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR4E2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.