OR4D6

Olfactory receptor 4D6 is a protein that in humans is encoded by the OR4D6 gene.[5]

OR4D6
Identifiers
Aliases	OR4D6, OR11-250, olfactory receptor family 4 subfamily D member 6
External IDs	MGI: 3031262 HomoloGene: 17339 GeneCards: OR4D6
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 59,456,938 bp[1] End 59,457,991 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 12,107,716 bp[2] End 12,115,897 bp[2]
Gene ontology Molecular function • G-protein coupled receptor activity • olfactory receptor activity • transmembrane signaling receptor activity • signal transducer activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • sensory perception of smell • detection of chemical stimulus involved in sensory perception of smell • detection of chemical stimulus involved in sensory perception • signal transduction • response to stimulus • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	219983	258673
Ensembl	ENSG00000166884	ENSMUSG00000067524
UniProt	Q8NGJ1	n/a
RefSeq (mRNA)	NM_001004708	NM_146678
RefSeq (protein)	NP_001004708	n/a
Location (UCSC)	Chr 11: 59.46 – 59.46 Mb	Chr 19: 12.11 – 12.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000166884 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067524 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4D6 olfactory receptor, family 4, subfamily D, member 6".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR4D6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.