X-His dipeptidase

Xaa-His dipeptidase (EC 3.4.13.3, aminoacylhistidine dipeptidase, carnosinase, homocarnosinase, dipeptidase M) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of Xaa!His dipeptides
Xaa-His dipeptidase
Identifiers
EC number3.4.13.3
CAS number9027-21-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This mammalian cytosolic enzyme also acts on anserine and homocarnosine.

References

  1. Hanson HT, Smith EL (June 1949). "Carnosinase; an enzyme of swine kidney". The Journal of Biological Chemistry. 179 (2): 789–801. PMID 18150012.
  2. Rosenberg A (December 1960). "The activation of carnosinase by divalent metal ions". Biochimica et Biophysica Acta. 45: 297–316. doi:10.1016/0006-3002(60)91454-2. PMID 13743376.
  3. Lenney JF, Kan SC, Siu K, Sugiyama GH (November 1977). "Homocarnosinase: a hog kidney dipeptidase with a broader specificity than carnosinase". Archives of Biochemistry and Biophysics. 184 (1): 257–66. doi:10.1016/0003-9861(77)90349-6. PMID 21630.
  4. Lenney JF (May 1990). "Separation and characterization of two carnosine-splitting cytosolic dipeptidases from hog kidney (carnosinase and non-specific dipeptidase)". Biological Chemistry Hoppe-Seyler. 371 (5): 433–40. doi:10.1515/bchm3.1990.371.1.433. PMID 2378680.
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