Valine—tRNA ligase

In enzymology, a valine-tRNA ligase (EC 6.1.1.9) is an enzyme that catalyzes the chemical reaction

ATP + L-valine + tRNAVal AMP + diphosphate + L-valyl-tRNAVal
valine-tRNA ligase
Identifiers
EC number6.1.1.9
CAS number9023-47-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are ATP, L-valine, and tRNA(Val), whereas its 3 products are AMP, diphosphate, and L-valyl-tRNA(Val).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-valine:tRNAVal ligase (AMP-forming). Other names in common use include valyl-tRNA synthetase, valyl-transfer ribonucleate synthetase, valyl-transfer RNA synthetase, valyl-transfer ribonucleic acid synthetase, valine transfer ribonucleate ligase, and valine translase. This enzyme participates in valine, leucine and isoleucine biosynthesis and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GAX, 1IVS, 1IYW, 1WK9, and 1WKA.

gollark: But at most points I don't think most people went around getting to decide on exactly what their values were and building societies to best embody them.
gollark: It's probably some complex bidirectional thing.
gollark: If your ethical system is "the greatest good is maximizing the number of paperclips in existence", it's entirely sensible to try and overthrow existing society to make paperclips.
gollark: Also, guess what, "still logical to agree with" implicitly assumes some values again!
gollark: I go around somewhat disagreeing with older ethical systems, and society hasn't collapsed yet.

See also

References
    • Berg P, Bergmann FH, Ofengand EJ, Dieckmann M (1961). "The enzymic synthesis of amino acyl derivatives of ribonucleic acid I. The mechanism of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid formation". J. Biol. Chem. 236: 1726–1734.
    • Bergmann FH, Berg P, Dieckmann M (1961). "The enzymic synthesis of amino acyl derivatives of ribonucleic acid II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli". J. Biol. Chem. 236: 1735–1740.


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