D-alanine—poly(phosphoribitol) ligase
In enzymology, a D-alanine—poly(phosphoribitol) ligase (EC 6.1.1.13) is an enzyme that catalyzes the chemical reaction
- ATP + D-alanine + poly(ribitol phosphate) AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
| D-alanine-poly(phosphoribitol) ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.1.1.13 | ||||||||
| CAS number | 9023-65-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are ATP, D-alanine, and poly(ribitol phosphate), whereas its 3 products are AMP, diphosphate, and O-D-alanyl-poly(ribitol phosphate).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is D-alanine:poly(phosphoribitol) ligase (AMP-forming). Other names in common use include D-alanyl-poly(phosphoribitol) synthetase, D-alanine: membrane acceptor ligase, D-alanine-D-alanyl carrier protein ligase, D-alanine-membrane acceptor ligase, and D-alanine-activating enzyme. This enzyme participates in d-alanine metabolism.
References
- BADDILEY J, NEUHAUS FC (1960). "The enzymic activation of D-alanine". Biochem. J. 75: 579–87. PMC 1204514. PMID 13795638.
- Reusch VM Jr, Neuhaus FC (1971). "D-Alanine: membrane acceptor ligase from Lactobacillus casei". J. Biol. Chem. 246 (20): 6136–43. PMID 4399593.
- Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W (1995). "Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation". J. Biol. Chem. 270 (26): 15598–606. doi:10.1074/jbc.270.26.15598. PMID 7797557.
- Heaton MP, Neuhaus FC (1994). "Role of the D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid". J. Bacteriol. 176 (3): 681–90. PMC 205105. PMID 8300523.
- Debabov DV, Heaton MP, Zhang Q, Stewart KD, Lambalot RH, Neuhaus FC (1996). "The D-Alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC". J. Bacteriol. 178 (13): 3869–76. PMC 232648. PMID 8682792.