Uronolactonase
In enzymology, an uronolactonase (EC 3.1.1.19) is an enzyme that catalyzes the chemical reaction
- D-glucurono-6,2-lactone + H2O D-glucuronate
| uronolactonase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.19 | ||||||||
| CAS number | 9025-93-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are D-glucurono-6,2-lactone and H2O, whereas its product is D-glucuronate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is D-glucurono-6,2-lactone lactonohydrolase. This enzyme is also called glucuronolactonase. This enzyme participates in ascorbate and aldarate metabolism.
References
- Winkelman J, Lehninger AL (October 1958). "Aldono- and uronolactonases of animal tissues". The Journal of Biological Chemistry. 233 (4): 794–9. PMID 13587494.
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