Thymidylate 5'-phosphatase

In enzymology, a thymidylate 5'-phosphatase (EC 3.1.3.35) is an enzyme that catalyzes the chemical reaction

thymidylate + H2O thymidine + phosphate
thymidylate 5'-phosphatase
Identifiers
EC number3.1.3.35
CAS number9026-80-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are thymidylate and H2O, whereas its two products are thymidine and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is thymidylate 5'-phosphohydrolase. Other names in common use include thymidylate 5'-nucleotidase, deoxythymidylate 5'-nucleotidase, thymidylate nucleotidase, deoxythymidylic 5'-nucleotidase, deoxythymidylate phosphohydrolase, and dTMPase.

References

    • Aposhian HV, Tremblay GY (1966). "Deoxythymidylate 5'-nucleotidase. Purification and properties of an enzyme found after infection of Bacillus subtilis with phage SP5C". J. Biol. Chem. 241 (21): 5095–101. PMID 4958986.


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