Small nucleolar RNA SNORA74

Small nucleolar RNA SNORA74 (U19) belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs.[1] Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNase MRP RNA suggests that U19 may be involved in pre-rRNA processing.[2][3]

Small nucleolar RNA SNORA74
Predicted secondary structure and sequence conservation of SNORA74
Identifiers
SymbolSNORA74
Alt. SymbolsU19
RfamRF00090
Other data
RNA typeGene; snRNA; snoRNA; H/ACA-box
Domain(s)Eukaryota
GO0006396 0005730
SO0000594
PDB structuresPDBe

References

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