Small nucleolar RNA Z13/snr52

Small nucleolar RNA snR52 (homologous to Z13) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z13 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

Small nucleolar RNA Z13/snr52
Predicted secondary structure and sequence conservation of snoZ13_snr52
Identifiers
SymbolsnoZ13_snr52
RfamRF00335
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GO0006396 0005730
SO0000593
PDB structuresPDBe

snoRNA snR52 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome;[2] subsequent work identified Z13 in Schizosaccharomyces pombe. Further experiments have shown that snR52 is transcribed by RNA polymerase III.[3][4]

References
  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Lowe, T. M.; Eddy, S. R. (February 1999). "A Computational Screen for Methylation Guide snoRNAs in Yeast". Science. 283 (5405): 1168–1171. Bibcode:1999Sci...283.1168L. doi:10.1126/science.283.5405.1168. PMID 10024243.
  3. Harismendy O, Gendrel CG, Soularue P, et al. (2003). "Genome-wide location of yeast RNA polymerase III transcription machinery". EMBO J. 22 (18): 4738–47. doi:10.1093/emboj/cdg466. PMC 212732. PMID 12970186.
  4. Marck C, Kachouri-Lafond R, Lafontaine I, Westhof E, Dujon B, Grosjean H (2006). "The RNA polymerase III-dependent family of genes in hemiascomycetes: comparative RNomics, decoding strategies, transcription and evolutionary implications". Nucleic Acids Res. 34 (6): 1816–35. doi:10.1093/nar/gkl085. PMC 1447645. PMID 16600899.


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