Small nucleolar RNA Z17

snoRNA Z17 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA Z17
Predicted secondary structure and sequence conservation of snoZ17
Identifiers
SymbolsnoZ17
RfamRF00266
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GO0006396 0005730
SO0001263
PDB structuresPDBe

snoRNA Z17 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA Z17B is predicted to guide the 2'-O-ribose methylation of 18S rRNA at position U121.[2] Two forms of this snoRNA are found in the intron of the ribosomal protein L23a gene.

References
  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Maden BE (1990). "The numerous modified nucleotides in eukaryotic ribosomal RNA". Progress in Nucleic Acid Research and Molecular Biology. Progress in Nucleic Acid Research and Molecular Biology. 39: 241–303. doi:10.1016/S0079-6603(08)60629-7. ISBN 978-0-12-540039-8. PMID 2247610.
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