Small nucleolar RNA SNORA76
In molecular biology, SNORA76 (also known as ACA62) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.[1]
| Small nucleolar RNA SNORA76 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA76 | |
| Identifiers | |
| Symbol | SNORA76 |
| Rfam | RF00598 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; HACA-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000594 |
| PDB structures | PDBe |
This snoRNA was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis.[2] ACA62 is proposed to guide the pseudouridylation of 18S rRNA U34 and U105.[2][3]
References
- Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
- Schattner P, Barberan-Soler S, Lowe TM (January 2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.
- Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158–162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
External links
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