SSBP2

Single-stranded DNA-binding protein 2 is a protein that in humans is encoded by the SSBP2 gene.[5][6][7]

SSBP2
Identifiers
Aliases	SSBP2, HSPC116, SOSS-B2, single stranded DNA binding protein 2
External IDs	OMIM: 607389 MGI: 1914220 HomoloGene: 22724 GeneCards: SSBP2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.1 Start 81,413,021 bp[1] End 81,751,797 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 91,460,283 bp[2] End 91,703,429 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • single-stranded DNA binding • DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding Cellular component • cytoplasm • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23635	66970
Ensembl	ENSG00000145687	ENSMUSG00000003992
UniProt	P81877	Q9CYZ8
RefSeq (mRNA)	NM_001256732 NM_001256733 NM_001256734 NM_001256735 NM_001256736 NM_012446 NM_001345886	NM_024186 NM_024272 NM_001360775 NM_001360776
RefSeq (protein)	NP_001243661 NP_001243662 NP_001243663 NP_001243664 NP_001243665 NP_001332815 NP_036578	NP_077148 NP_077234 NP_001347704 NP_001347705
Location (UCSC)	Chr 5: 81.41 – 81.75 Mb	Chr 13: 91.46 – 91.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000145687 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003992 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
7. "Entrez Gene: SSBP2 single-stranded DNA binding protein 2".

Further reading

• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Castro P, Liang H, Liang JC, Nagarajan L (2003). "A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity". Genomics. 80 (1): 78–85. doi:10.1006/geno.2002.6805. PMID 12079286.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liang H, Samanta S, Nagarajan L (2005). "SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells". Oncogene. 24 (16): 2625–34. doi:10.1038/sj.onc.1208167. PMID 15782145.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Fleisig HB, Orazio NI, Liang H, et al. (2007). "Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes". Oncogene. 26 (33): 4797–805. doi:10.1038/sj.onc.1210281. PMID 17311003.