MCM5

MCM5
Identifiers
Aliases	MCM5, CDC46, P1-CDC46, minichromosome maintenance complex component 5, MGORS8
External IDs	OMIM: 602696 MGI: 103197 HomoloGene: 4904 GeneCards: MCM5
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	35,425,431 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	75,128,439 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • DNA binding; • GO:0004003 DNA helicase activity; • DNA replication origin binding; • chromatin binding; • GO:0001948 protein binding; • hydrolase activity; • ATP binding; • GO:0008026 helicase activity; • single-stranded DNA binding; • GO:0043142 single-stranded DNA helicase activity; • GO:0043140 3'-5' DNA helicase activity;
Cellular component	• MCM complex; • membrane; • nuclear chromosome, telomeric region; • cell nucleus; • nucleoplasm; • cytoplasm; • cytosol;
Biological process	• G1 phase; • DNA replication; • cell cycle; • DNA duplex unwinding; • DNA replication initiation; • G1/S transition of mitotic cell cycle; • double-strand break repair via break-induced replication; • pre-replicative complex assembly involved in nuclear cell cycle DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	4174
	17218
	ENSG00000100297
	ENSMUSG00000005410
	P33992
	P49718
	NM_006739
	NM_008566; NM_001302540
	NP_006730
	NP_001289469; NP_032592
	Wikidata
View/Edit Human	View/Edit Mouse

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.[5][6][7]

Function

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.[7]

gollark: Perhaps they're semirandom. Perhaps I devise bespoke bluffs by myself and then share them. Perhaps my bluffs are optimized automatically via testing against high-fidelity computer simulations of all other participants. Perhaps I don't make bluffs but merely disseminate cognitohazards causing perception of bluffs. Perhaps my every word and bluff is meticulously generated to produce minimum guessing of me. Perhaps I never bluff and every word I say is accurate.

gollark: I generate my bluffs via RNG now to avoid the terribleness of human random number generation (heavpoot has data on this), unless I don't and am trying to trick you into not making inferences from them.

gollark: Unless I didn't but am *not* trying to fool you all.

gollark: Unless I didn't and am trying to fool you all, of course.

gollark: I attempted to completely leave any chat here in the guessing phase out of my decision-making.

Interactions

MCM5 has been shown to interact with:

Cell division cycle 7-related protein kinase,[8]
MCM2,[8][9]
MCM3,[8][9]
MCM7,[8][9][10]
ORC2L,[8]
ORC6L,[8] and
STAT1.[9][11]

References

GRCh38: Ensembl release 89: ENSG00000100297 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000005410 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). "Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5". Cytogenet Cell Genet. 73 (4): 317–21. doi:10.1159/000134366. PMID 8751386.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
"Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)".
Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
DaFonseca CJ, Shu F, Zhang JJ (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027.
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.
Zhang JJ, Zhao Y, Chait BT, Lathem WW, Ritzi M, Knippers R, Darnell JE (Dec 1998). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation". EMBO J. 17 (23): 6963–71. doi:10.1093/emboj/17.23.6963. PMC 1171044. PMID 9843502.

Burkhart R, Schulte D, Hu D, Musahl C, Göhring F, Knippers R (1995). "Interactions of human nuclear proteins P1Mcm3 and P1Cdc46". Eur. J. Biochem. 228 (2): 431–8. doi:10.1111/j.1432-1033.1995.tb20281.x. PMID 7705359.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hu B, Burkhart R, Schulte D, Musahl C, Knippers R (1994). "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins". Nucleic Acids Res. 21 (23): 5289–93. doi:10.1093/nar/21.23.5289-a. PMC 310560. PMID 8265339.
Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650.
Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.
Tsuruga H, Yabuta N, Hashizume K, Ikeda M, Endo Y, Nojima H (1997). "Expression, nuclear localization and interactions of human MCM/P1 proteins". Biochem. Biophys. Res. Commun. 236 (1): 118–25. doi:10.1006/bbrc.1997.6865. PMID 9223437.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang JJ, Zhao Y, Chait BT, Lathem WW, Ritzi M, Knippers R, Darnell JE (1999). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation". EMBO J. 17 (23): 6963–71. doi:10.1093/emboj/17.23.6963. PMC 1171044. PMID 9843502.
Ohtani K, Iwanaga R, Nakamura M, Ikeda M, Yabuta N, Tsuruga H, Nojima H (1999). "Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F". Oncogene. 18 (14): 2299–309. doi:10.1038/sj.onc.1202544. PMID 10327050.
DaFonseca CJ, Shu F, Zhang JJ (2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027.
Going JJ, Keith WN, Neilson L, Stoeber K, Stuart RC, Williams GH (2002). "Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa". Gut. 50 (3): 373–7. doi:10.1136/gut.50.3.373. PMC 1773132. PMID 11839717.
Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J (2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. doi:10.1126/science.1097639. PMID 15232106.
Yu Z, Feng D, Liang C (2004). "Pairwise interactions of the six human MCM protein subunits". J. Mol. Biol. 340 (5): 1197–206. doi:10.1016/j.jmb.2004.05.024. PMID 15236977.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100297 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005410 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8751386-5] Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). "Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5". Cytogenet Cell Genet. 73 (4): 317–21. doi:10.1159/000134366. PMID 8751386.

[pmid10591208-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.

[entrez-7] "Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)".

[pmid12614612-8] Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.

[pmid11248027-9] DaFonseca CJ, Shu F, Zhang JJ (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027.

[pmid9099751-10] Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.

[pmid9843502-11] Zhang JJ, Zhao Y, Chait BT, Lathem WW, Ritzi M, Knippers R, Darnell JE (Dec 1998). "Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation". EMBO J. 17 (23): 6963–71. doi:10.1093/emboj/17.23.6963. PMC 1171044. PMID 9843502.

MCM5

Function

See also

Interactions

References

Further reading