POLE4
Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.[5]
Function
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[5]
gollark: Hmm, I think I actually know someone with one of those still.
gollark: Does anyone know of phones with removable batteries (and good availability of said batteries), no notch, an LCD (not OLED) screen, a μSD card slot, decent battery life, and some custom ROM support, which is still produced or fairly available used? Do any even exist now?!
gollark: Since my current device doesn't have a replaceable battery, and is becoming increasingly less usable, I don't know *what* I'll replace it with which won't break in the same ways.
gollark: My *previous* phone became unusable due to not actually holding in μUSB cables, preventing me from charging it. Though I think that's partly because the port was mildly out of spec.
gollark: Also, my phone (~2 years old) has a USB-C port which cables randomly come loose from now.
References
- GRCh38: Ensembl release 89: ENSG00000115350 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000030042 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit".
Further reading
- Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
- Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
- Wang YL, Faiola F, Xu M, Pan S, Martinez E (2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". J. Biol. Chem. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.
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