POLE4

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.[5]

POLE4
Identifiers
Aliases	POLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDs	OMIM: 607269 MGI: 1914229 HomoloGene: 41339 GeneCards: POLE4
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 74,958,643 bp[1] End 74,970,128 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 82,618,992 bp[2] End 82,705,365 bp[2]
Gene ontology Molecular function • transferase activity • DNA binding • DNA-directed DNA polymerase activity • nucleotidyltransferase activity • GO:0001948 protein binding • protein heterodimerization activity Cellular component • Ada2/Gcn5/Ada3 transcription activator complex • epsilon DNA polymerase complex • cell nucleus • nucleoplasm Biological process • histone H3 acetylation • DNA biosynthetic process • G1/S transition of mitotic cell cycle • DNA replication initiation • telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56655	66979
Ensembl	ENSG00000115350	ENSMUSG00000030042
UniProt	Q9NR33	Q9CQ36
RefSeq (mRNA)	NM_019896	NM_025882 NM_001370295
RefSeq (protein)	NP_063949	NP_080158 NP_001357224
Location (UCSC)	Chr 2: 74.96 – 74.97 Mb	Chr 6: 82.62 – 82.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000115350 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030042 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit".

Further reading

• Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
• Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
• Wang YL, Faiola F, Xu M, Pan S, Martinez E (2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". J. Biol. Chem. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.