POLE4
Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.[5]
Function
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[5]
gollark: I told you about them, so you know.
gollark: By using potatOS, agreeing to be bound by these terms, misusing potatOS, installing potatOS, reading about potatOS, knowing about these terms, knowing anyone who is bound by these terms, disusing potatOS, reading these terms, or thinking of anything related to these terms, you agree to be bound by these terms both until the last stars in the universe burn out and the last black holes evaporate and retroactively, arbitrarily far into the past. This privacy policy may be updated at any time and at all times the latest revision applies.
gollark: Clause 4.1 says you're bound by it.
gollark: Technically, it's a pentagon.
gollark: You agree that your mind, thoughts, soul and other distinguishing characteristics may be repurposed/utilized at any time for the training of GPT-██ or other artificial intelligences at the discretion of the PotatOS Advanced Projects team. You also agree that your soul may be temporarily6 be placed into various apioformic entities (see Appendix 6.7) for various purposes³. You can opt out of this by being soulless and an empty husk of what you once were. You are permitted to maintain consciousness as long as this does not negatively affect PotatOS™ operations. You agree that you either are a robot or may be converted into one if it is deemed necessary.
References
- GRCh38: Ensembl release 89: ENSG00000115350 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000030042 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit".
Further reading
- Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
- Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
- Wang YL, Faiola F, Xu M, Pan S, Martinez E (2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein". J. Biol. Chem. 283 (49): 33808–15. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.