Pyroglutamyl-peptidase II

Pyroglutamyl-peptidase II (EC 3.4.19.6, thyroliberinase, pyroglutamyl aminopeptidase II, thyrotropin-releasing factor pyroglutamate aminopeptidase, pyroglutamate aminopeptidase II, pyroglutamyl peptidase II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading peptidase, TRH aminopeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Release of the N-terminal pyroglutamyl group from pGlu--His-Xaa tripeptides and pGlu--His-Xaa-Gly tetrapeptides
Pyroglutamyl-peptidase II
Identifiers
EC number3.4.19.6
CAS number60063-88-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is highly specific for thyrotropin releasing hormone.

Human gene

TRHDE - thyrotropin releasing hormone degrading enzyme

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References

  1. Bauer K, Nowak P (September 1979). "Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond". European Journal of Biochemistry. 99 (2): 239–46. doi:10.1111/j.1432-1033.1979.tb13250.x. PMID 115687.
  2. O'Connor B, O'Cuinn G (July 1985). "Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain". European Journal of Biochemistry. 150 (1): 47–52. doi:10.1111/j.1432-1033.1985.tb08986.x. PMID 2862039.
  3. Wilk, S.; Wilk, E.K. (1989). "Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme". Neurochem. Int. 15: 81–89. doi:10.1016/0197-0186(89)90079-x.
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