Poly(3-hydroxybutyrate) depolymerase

In enzymology, a poly(3-hydroxybutyrate) depolymerase (EC 3.1.1.75) is an enzyme that catalyzes the chemical reaction

poly[(R)-3-hydroxybutanoate]n + H2O poly[(R)-3-hydroxybutanoate]n-x + poly[(R)-3-hydroxybutanoate]x; x 1-5
poly(3-hydroxybutyrate) depolymerase
Identifiers
EC number3.1.1.75
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are [[poly[(R)-3-hydroxybutanoate]n]] and H2O, whereas its two products are [[poly[(R)-3-hydroxybutanoate]n-x]] and [[poly[(R)-3-hydroxybutanoate]x; x]].

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is poly[(R)-3-hydroxybutanoate] hydrolase. Other names in common use include PHB depolymerase, poly(3HB) depolymerase, poly[(R)-hydroxyalkanoic acid] depolymerase, poly(HA) depolymerase, poly(HASCL) depolymerase, and poly[(R)-3-hydroxybutyrate] hydrolase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2D80 and 2D81.

gollark: That won't actually happen. Which is a bit of an oversight, I must admit.
gollark: ...
gollark: I doubt it, but go on.
gollark: This isn't exactly addressing that, but basically for obvious security reasons all user-controlled things must run in the sandbox.
gollark: Please read the docs a bit: https://git.osmarks.tk/osmarks/potatOS#user-content-architecture

References
    • Jendrossek D (2001). "Microbial degradation of polyesters". Adv. Biochem. Eng. Biotechnol. 71: 293–325. doi:10.1007/3-540-40021-4_10. PMID 11217416.
    • Prieto MA, Garcia JL, Martinez M, Luengo JM (1999). "Novel biodegradable aromatic plastics from a bacterial source Genetic and biochemical studies on a route of the phenylacetyl-coa catabolon". J. Biol. Chem. 274 (41): 29228–41. doi:10.1074/jbc.274.41.29228. PMID 10506180.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.