Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Identifiers
EC number3.1.3.78
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme participates in one of the mammalian pathways for degradation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2].

References

  1. Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B (October 2002). "Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology". The EMBO Journal. 21 (19): 5069–78. doi:10.1093/emboj/cdf522. PMC 129044. PMID 12356723.
  2. Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW (December 2005). "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases". Proceedings of the National Academy of Sciences of the United States of America. 102 (52): 18854–9. doi:10.1073/pnas.0509740102. PMC 1323219. PMID 16365287.
  3. Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW (October 2007). "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 104 (43): 16834–9. doi:10.1073/pnas.0708189104. PMC 2040409. PMID 17940011.
  4. Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S (April 2007). "Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase". The Journal of General Physiology. 129 (4): 267–83. doi:10.1085/jgp.200609656. PMC 2151621. PMID 17389247.
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