Phosphatidylinositol-3-phosphatase

In enzymology, a phosphatidylinositol-3-phosphatase (EC 3.1.3.64) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O 1-phosphatidyl-1D-myo-inositol + phosphate
phosphatidylinositol-3-phosphatase
Identifiers
EC number3.1.3.64
CAS number124248-47-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 1-phosphatidyl-1D-myo-inositol 3-phosphate and H2O, whereas its two products are 1-phosphatidyl-1D-myo-inositol and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase. Other names in common use include inositol-1,3-bisphosphate 3-phosphatase, inositol 1,3-bisphosphate phosphatase, inositol-polyphosphate 3-phosphatase, D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase, and phosphatidyl-3-phosphate 3-phosphohydrolase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1LW3 and 1M7R.

gollark: I bet you can get ffmpeg on phones somehow.
gollark: You can fit Shrek in *very* low quality in 8MiB!
gollark: The amazing power of MODERN CODECS™.
gollark: Well, they seem to have tried to do that initially for a bit, then gave up (at least for my year), leaving us doing something like two lessons a week but being set a bunch of random papers to do (which I mostly ignored because they are extremely boring).
gollark: I'm glad school is over for me now and I can avoid worrying about them doing stupid things.

References
    • Lips DL, Majerus PW (1989). "The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells". J. Biol. Chem. 264 (33): 19911–5. PMID 2555336.
    • Caldwell KK, Lips DL, Bansal VS, Majerus PW (1991). "Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate". J. Biol. Chem. 266 (27): 18378–86. PMID 1655747.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.