Phosphatidylglycerophosphatase
In enzymology, a phosphatidylglycerophosphatase (EC 3.1.3.27) is an enzyme that catalyzes the chemical reaction
- phosphatidylglycerophosphate + H2O phosphatidylglycerol + phosphate
| Phosphatidylglycerophosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | PAP2 | ||||||||
| Pfam | PF01569 | ||||||||
| OPM superfamily | 409 | ||||||||
| OPM protein | 5jwy | ||||||||
| |||||||||
| phosphatidylglycerophosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.27 | ||||||||
| CAS number | 9033-46-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are phosphatidylglycerophosphate and H2O, whereas its two products are phosphatidylglycerol and phosphate.[1]
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is phosphatidylglycerophosphate phosphohydrolase. Other names in common use include phosphatidylglycerol phosphate phosphatase, phosphatidylglycerol phosphatase, and PGP phosphatase. This enzyme participates in glycerophospholipid metabolism.
This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad.[2]
References
- Chang YY, Kennedy EP (1967). "Phosphatidyl glycerophosphate phosphatase". J. Lipid Res. 8 (5): 456–62. PMID 4292860.
- Osman, Christof; Haag, Mathias; Wieland, Felix T; Brügger, Britta; Langer, Thomas (2010). "A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4". The EMBO Journal. 29 (12): 1976–1987. doi:10.1038/emboj.2010.98. ISSN 0261-4189. PMC 2892375. PMID 20485265.