Phosphatidylglycerophosphatase

In enzymology, a phosphatidylglycerophosphatase (EC 3.1.3.27) is an enzyme that catalyzes the chemical reaction

phosphatidylglycerophosphate + H2O phosphatidylglycerol + phosphate
Phosphatidylglycerophosphatase
Identifiers
SymbolPAP2
PfamPF01569
OPM superfamily409
OPM protein5jwy
phosphatidylglycerophosphatase
Identifiers
EC number3.1.3.27
CAS number9033-46-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are phosphatidylglycerophosphate and H2O, whereas its two products are phosphatidylglycerol and phosphate.[1]

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is phosphatidylglycerophosphate phosphohydrolase. Other names in common use include phosphatidylglycerol phosphate phosphatase, phosphatidylglycerol phosphatase, and PGP phosphatase. This enzyme participates in glycerophospholipid metabolism.

This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad.[2]

References

  1. Chang YY, Kennedy EP (1967). "Phosphatidyl glycerophosphate phosphatase". J. Lipid Res. 8 (5): 456–62. PMID 4292860.
  2. Osman, Christof; Haag, Mathias; Wieland, Felix T; Brügger, Britta; Langer, Thomas (2010). "A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4". The EMBO Journal. 29 (12): 1976–1987. doi:10.1038/emboj.2010.98. ISSN 0261-4189. PMC 2892375. PMID 20485265.


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