Oropouche orthobunyavirus

Oropouche orthobunyavirus (OROV) is one of the most common orthobunyaviruses. When OROV infects humans, it causes a rapid fever illness called Oropouche fever. OROV was originally reported in Trinidad and Tobago in 1955 from the blood sample of a fever patient and from a pool of Coquillettidia venezuelensis mosquitoes. In 1960, OROV was isolated from a sloth (Bradypus tridactylus) and a pool of Ochlerotatus (Ochlerotatus) serratus mosquitoes in Brazil.[1] The virus is considered a public health threat in tropical and subtropical areas of Central and South America, with over half million infected people as of 2005.[2] OROV is considered to be an arbovirus due to the method of transmission by the mosquitoes Aedes serratus and Culex quinquefasciatus among sloths, marsupials, primates, and birds.[3]

Oropouche orthobunyavirus
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Peribunyaviridae
Genus: Orthobunyavirus
Species:
Oropouche orthobunyavirus

Epidemic Sites

Between 1961 and 1980, OROV was reported in the northern state of Pará, Brazil, and from 1980 to 2004, OROV had spread to the Amazonas, Amapá, Acre, Rondônia, Tocantis, and Maranhão.[2] The virus would cause Oropouche fever, an urban arboviral disease that has since resulted in >30 epidemics during 1960–2009.[4]

Virology

Currently, based on the small segment (SRNA) genetic information, there are 4 major genotypes (I–IV) of OROV. Genotype I was isolated from strains in Acre, Amazonas, Maranhão, Tocantis, Pará, Trinidad, and Tobago. Genotype II was obtained during the spread in Amapá, Pará, Rondônia, and Peru. Genotype III was isolated from samples in Acre, Minas Gerais, Panama, and Rondônia. The final genotype IV was isolated from Amazonas.[1]

Dispersion

A possible dispersal could be predicted for the four genotypes based on time-scaled analysis and epidemiologic data association. Genotype I possibly dispersed towards western Pará, Trinidad, and Tobago. After, genotype I progressed towards Amazonas, Acre, Maranhao, and Tocantins. Genotype II possibly emerged in Amapá, Pará, Rondônia, and Peru at the same time. Genotype III emerged in Rondônia, moved towards Panama, Acre, and Maranhão. From Maranhão, the genotype progressed towards Minas Gerais. Finally, genotype IV emerged from the city of Manaus and Amazonas.[4]

Experimentation and Research

OROV has been used extensively in testing with Hela cells to study the mechanisms of apoptosis induced by the virus. It was found that OROV causes apoptosis by DNA fragmentation. In UV-inactivated OROV, virus-receptor binding was not enough and that viral uncoating and replication were needed to induce apoptosis.[5]

gollark: The thing is that unless you have a perfectly straight run light would still need to bounce off the walls of it (which would need to be very very good mirrors, which is very hard).
gollark: No.
gollark: I guess just solid walls for the interior bit of the cable.
gollark: Also, people would probably complain if their fiber optic imploded.
gollark: I'm sure so many things will be affected by, what, nanoseconds less latency.

References
  1. Vasconcelos, Helena Baldez; Nunes, Márcio R.T.; Casseb, Lívia M.N.; Carvalho, Valéria L.; Pinto da Silva, Eliana V.; Silva, Mayra; Casseb, Samir M.M.; Vasconcelos, Pedro F.C. (2011). "Molecular Epidemiology of Oropouche Virus, Brazil". Emerging Infectious Diseases. 17 (5): 800–806. doi:10.3201/eid1705.101333. ISSN 1080-6040. PMC 3321770. PMID 21529387.
  2. Nunes, Marcio Roberto Teixeira; et al. (2005). "Oropouche virus isolation, southeast Brazil" (PDF). Emerging Infectious Diseases. 11 (10): 1610–1613. doi:10.3201/eid1110.050464. PMC 3366749. PMID 16318707.
  3. Mourao, Maria Paula G.; et al. (2009). "Oropouche Fever Outbreak, Manaus, Brazil, 2007–2008" (PDF). Emerging Infectious Diseases. 15 (12): 2063–2064. doi:10.3201/eid1512.090917. PMC 3044544. PMID 19961705.
  4. "Molecular Epidemiology of Oropouche Virus, Brazil". Retrieved 2013-04-08.
  5. Acrani, Gustavo Olszanski; Gomes, Rogério; Proença-Módena, José Luiz; da Silva, Andrei Furlan; Oliveira Carminati, Patricia; Silva, Maria Lucia; Santos, Rodrigo Ivo Marques; Arruda, Eurico (2010). "Apoptosis induced by Oropouche virus infection in HeLa cells is dependent on virus protein expression". Virus Research. 149 (1): 56–63. doi:10.1016/j.virusres.2009.12.013. ISSN 0168-1702. PMID 20080135.
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