Oleoyl-(acyl-carrier-protein) hydrolase

In enzymology, an oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14) is an enzyme that catalyzes the chemical reaction

oleoyl-[acyl-carrier-protein] + H2O [acyl-carrier-protein] + oleate
acyl-ACP thioesterase
Identifiers
EC number3.1.2.14
CAS number68009-83-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are [[oleoyl-[acyl-carrier-protein]]] and H2O, whereas its two products are acyl-carrier-protein and oleate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is oleoyl-[acyl-carrier-protein] hydrolase. Other names in common use include acyl-[acyl-carrier-protein] hydrolase, acyl-ACP-hydrolase, acyl-acyl carrier protein hydrolase, oleoyl-ACP thioesterase, and oleoyl-acyl carrier protein thioesterase. This enzyme participates in fatty acid biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2OWN and 2PFF.

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References
    • Ohlrogge JB, Shine WE, Stumpf PK (1978). "Fat metabolism in higher plants. Characterization of plant acyl-ACP and acyl-CoA hydrolases". Arch. Biochem. Biophys. 189 (2): 382–91. doi:10.1016/0003-9861(78)90225-4. PMID 30409.
    • Shine WE, Mancha M, Stumpf PK (1976). "Fat metabolism in higher plants. The function of acyl thioesterases in the metabolism of acyl-coenzymes A and acyl-acyl carrier proteins". Arch. Biochem. Biophys. 172 (1): 110–6. doi:10.1016/0003-9861(76)90054-0. PMID 3134.


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