Membrane Pro-X carboxypeptidase

Membrane Pro-Xaa carboxypeptidase (EC 3.4.17.16, carboxypeptidase P, microsomal carboxypeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Release of a C-terminal residue other than proline, by preferential cleavage of a prolyl bond
Membrane Pro-Xaa carboxypeptidase
Identifiers
EC number3.4.17.16
CAS number9075-64-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This is one of the renal brush border exopeptidases

References

  1. Dehm P, Nordwig A (December 1970). "The cleavage of prolyl peptides by kidney peptidases. Isolation of a microsomal carboxypeptidase from swine kidney". European Journal of Biochemistry. 17 (2): 372–7. doi:10.1111/j.1432-1033.1970.tb01175.x. PMID 5500406.
  2. Booth AG, Hubbard LM, Kenny AJ (May 1979). "Proteins of the kidney microvillar membrane. Immunoelectrophoretic analysis of the membrane hydrolases: identification and resolution of the detergent- and proteinase-solubilized forms". The Biochemical Journal. 179 (2): 397–405. doi:10.1042/bj1790397. PMC 1186637. PMID 486090.
  3. Hedeager-Sørensen S, Kenny AJ (July 1985). "Proteins of the kidney microvillar membrane. Purification and properties of carboxypeptidase P from pig kidneys". The Biochemical Journal. 229 (1): 251–7. doi:10.1042/bj2290251. PMC 1145174. PMID 4038259.
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