Leucyl/cystinyl aminopeptidase

Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is an enzyme of the aminopeptidase group that in humans is encoded by the LNPEP gene.[5][6]

LNPEP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLNPEP, CAP, IRAP, P-LAP, PLAP, leucyl/cystinyl aminopeptidase, leucyl and cystinyl aminopeptidase
External IDsOMIM: 151300 MGI: 2387123 HomoloGene: 21148 GeneCards: LNPEP
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q15Start96,935,394 bp[1]
End97,037,513 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

4012

240028

Ensembl

ENSG00000113441

ENSMUSG00000023845

UniProt

Q9UIQ6

Q8C129

RefSeq (mRNA)

NM_175920
NM_005575

NM_172827

RefSeq (protein)

NP_005566
NP_787116

NP_766415

Location (UCSC)Chr 5: 96.94 – 97.04 MbChr 17: 17.52 – 17.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a zinc-dependent aminopeptidase (metalloexopeptidase) that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]

Mutations in this gene have been associated to psoriasis risk.(doi:10.1038/jid.2013.317)

Interactions

Cystinyl aminopeptidase has been shown to interact with TNKS2.[7][8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000113441 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023845 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rogi T, Tsujimoto M, Nakazato H, Mizutani S, Tomoda Y (February 1996). "Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family". J Biol Chem. 271 (1): 56–61. doi:10.1074/jbc.271.1.56. PMID 8550619.
  6. "Entrez Gene: LNPEP leucyl/cystinyl aminopeptidase".
  7. Sbodio, Juan I; Chi Nai-Wen (August 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061.
  8. Chi, N W; Lodish H F (December 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. 275 (49): 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299.
  9. Sbodio, Juan I; Lodish Harvey F; Chi Nai-Wen (February 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774.

Further reading


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