HLA-B73

HLA-B73 (B73) is an HLA-B serotype. The serotype identifies the HLA-B*7301 gene product.[1] Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes.[2] B73 is more common in Western Indian Ocean, Mediterranean and Africa. (For terminology help see: HLA-serotype tutorial)




major histocompatibility complex (human), class I, B73
Alleles	B*7301
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*7301
Locus	chr.6 6p21.31

Serotype

B*73:01 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*18:06, B*46:01, and B*55:03.[3]

B73 serotype recognition of B*7301 allele-group gene products[4]
B*73	B73	Other	Sample
allele	%	%	size (N)
7301	22	69	106

B*7301 frequencies

**HLA B*7301 frequencies**
		freq
ref.	Population	(%)
[5]	Parsi (Karachi, Pakistan)	4.9
[5]	United Arab Emirates	2.0
[5]	Italy	2.0
[5]	Seri (Sonora, Mexico)	1.5
[5]	Purépecha (Michoacán, Mexico)	1.5
[5]	Jews (Israel) (*2 studies)	1.2
[5]	Beti (Cameroon)	1.1
[5]	Casablanca (Morocco)	0.9
[5]	Tbilisi (Georgia)	0.9
[5]	Mossi (Burkina Faso)	0.9
[5]	Bulgaria	0.9
[5]	Sudanese	0.8
[5]	Tuva (Russia) (2)	0.8
[5]	Oman	0.8
[5]	Bamileke (Cameroon)	0.6
[5]	Pathan (Pakistan)	0.5
[5]	Khalkha (Mongolia)	0.5
[5]	Druse Arabs (Israel)	0.5
[5]	Baloch (Iran)	0.5
[5]	Manchester (England)	0.5
[5]	Algeria (1)	0.5
[5]	Turkey	0.4
[5]	Amman (Jordan)	0.3
[5]	Shona (Harare, Zimbabwe)	0.2
[5]	Republic of Macedonia	0.2
[5]	Nandi (Kenya)	0.2
[5]	Luo (Kenya)	0.2
[5]	Campania (Italy)	0.2
[5]	Greece	0.2

gollark: I could probably do it, but apiaries.

gollark: Am I SERIOUSLY going to have to write my own status page implementation?

gollark: Although I did have to mess with some config to make it crosscompile right.

gollark: ircsysmon, my trivial nim program for IRC-based system monitoring (it made sense at the same time), takes about 10 seconds at most to crosscompile.

gollark: That is quite a while.

References

Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
Hoffmann HJ, Kristensen TJ, Jensen TG, Graugaard B, Lamm LU (1995). "Antigenic characteristics and cDNA sequences of HLA-B73". Eur. J. Immunogenet. 22 (3): 231–40. doi:10.1111/j.1744-313X.1995.tb00237.x. PMID 8547229.
Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.
derived from IMGT/HLA
Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)

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[pmid15787720-1] Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.

[pmid8547229-2] Hoffmann HJ, Kristensen TJ, Jensen TG, Graugaard B, Lamm LU (1995). "Antigenic characteristics and cDNA sequences of HLA-B73". Eur. J. Immunogenet. 22 (3): 231–40. doi:10.1111/j.1744-313X.1995.tb00237.x. PMID 8547229.

[3] Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.

[4] rived from IMGT/HLA

[pmid12753660-5] Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)