HLA-B18

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products.[1] (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

major histocompatibility complex (human), class I, B18
Alleles B*1801
Alleles B*1802
Alleles B*1803
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*1801
EBI-HLA B*1802
EBI-HLA B*1803
Locus chr.6 6p21.31

Serotype

B*18:06 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*46:01, B*55:03, and B*73:01.[2]

B18 serotype recognition of Some HLA B*18 allele-group gene products[3]
B*18B18 Sample
allele%%size (N)
1801961641
18029031
18038329

Allele frequencies
HLA B*1801 frequencies
freq
ref.Population(%)
[4]Italy North pop 116.7
[4]Croatia11.3
[4]Georgia Svaneti Svans11.3
[4]Romanian11.3
[4]Portugal South11.2
[4]Singapore Riau Malay9.9
[4]Bulgaria9.1
[4]Israel Arab Druse8.5
[4]Azores Central Islands8.0
[4]Portugal Centre8.0
[4]Finland7.8
[4]Azores Santa Maria and Sao Miguel7.7
[4]Czech Republic7.5
[4]India Jalpaiguri Toto7.5
[4]Iran Baloch7.1
[4]Philippines Ivatan7.0
[4]Thailand6.7
[4]Tunisia6.7
[4]Portugal North6.5
[4]Zimbabwe Harare Shona6.4
[4]Madeira6.2
[4]Mexico Mestizos6.1
[4]Kenya5.9
[4]Belgium5.1
[4]Morocco Nador Metalsa Class I5.1
[4]Singapore Javanese Indonesians5.1
[4]Israel Ashkenazi and Non Ashkenazi Jews5.0
[4]Uganda Kampala5.0
[4]Kenya Nandi4.8
[4]Oman4.7
[4]Georgia Tibilisi Georgians4.6
[4]Bulgaria Gipsy4.5
[4]France South East4.3
[4]Kenya Luo4.3
[4]Ireland South4.2
[4]Russia Arkhangelsk Pomors4.0
[4]Azores Terceira Island3.9
[4]Guinea Bissau3.8
[4]India New Delhi3.8
[4]Spain Eastern Andalusia Gipsy3.5
[4]Australia New South Wales3.4
[4]Georgia Tibilisi Kurds3.4
[4]Zambia Lusaka3.4
[4]Cameroon Yaounde2.7
[4]Senegal Niokholo Mandenka2.7
[4]Cameroon Beti2.3
[4]Ivory Coast Akan Adiopodoume2.3
[4]Sudanese2.3
[4]Saudi Arabia Guraiat and Hail2.2
[4]South African Natal Zulu2.0
[4]Thailand2.0
[4]India Mumbai Marathas1.9
[4]New Caledonia1.9
[4]Papua New Guinea Wanigela1.5
[4]Cameroon Bamileke1.3
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References
  1. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.
  3. derived from IMGT/HLA
  4. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)
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