HLA-B53
HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. (For terminology help see: HLA-serotype tutorial)
major histocompatibility complex (human), class I, B53 | ||
| Alleles | B*5301 B*5302 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*5301 | |
| EBI-HLA | B*5302 | |
| Locus | chr.6 6p21.31 | |
Serotype
| B*53 | B53 | B35 | Sample |
| allele | % | % | size (N) |
| 5301 | 86 | 5 | 3054 |
| 5302 | 80 | 20 | 5 |
B*5301 allele frequencies
| freq | ||
| ref. | Population | (%) |
| [4] | Akan Adiopodoume (Ivory Coast) | 22.7 |
| [4] | Rimaibe (Burkina Faso) | 22.3 |
| [4] | Mossi (Burkina Faso) | 20.8 |
| [4] | Bandiagara (Mali) | 15.9 |
| [4] | Sawa (Cameroon) | 11.5 |
| [4] | Lusaka (Zambia) | 10.2 |
| [4] | Baka Pygmy (Cameroon) | 10.0 |
| [4] | Guinea Bissau | 10.0 |
| [4] | Harare Shona (Zimbabwe) | 9.3 |
| [4] | Baloch (Iran) | 9.1 |
| [4] | Kenya | 8.7 |
| [4] | Canoncito Navajo (USA) | 8.5 |
| [4] | Brahui (Pakistan) | 7.7 |
| [4] | Niokholo Mandenka (Senegal) | 5.3 |
| [4] | Croatia (2) | 5.0 |
| [4] | Mongolia Khoton Tarialan | 4.9 |
| [4] | Pakistan Baloch | 4.6 |
| [4] | Casablanca (Morocco) | 3.7 |
| [4] | Arratia Basque (Spain) | 3.3 |
| [4] | Crete (Greece) | 3.2 |
| [4] | Israel Arab Druse | 2.5 |
| [4] | Israel Gaza Palestinians | 2.4 |
| [4] | Amman (Jordan ) | 2.4 |
| [4] | Tunis (Tunisia ) | 2.3 |
| [4] | Tuva (2) (Russia) | 2.2 |
| [4] | Oman | 2.1 |
| [4] | France South East | 1.6 |
| [4] | Saudi Arabia Guraiat and Hail | 1.5 |
| [4] | Berber (Morocco) | 1.4 |
| [4] | Georgia Svaneti Svans | 1.3 |
| [4] | Mongolia Khalkh Ulaanbaatar | 1.2 |
| [4] | Spain Catalonia Girona | 1.1 |
| [4] | India Andhra Pradesh Golla | 1.0 |
| [4] | Mongolia Khalha | 1.0 |
Haplotype frequencies
| freq | ||
| ref. | Population | (%) |
| Zimbabwe | 3.6 | |
| [4] | Zambia Lusaka | 2.3 |
| N. Afr. Negroid | 2.1 | |
| [4] | Kenya Luo | 1.9 |
| [4] | Cameroon Yaounde | 1.7 |
| [5] | African American | 1.5 |
| [4] | Kenya Nandi | 1.3 |
| [5] | American Hispanic | 0.2 |
| ' | ||
| A*6802 : Cw*0401 : B*5301 | ||
| [4] | Mali Bandihagara | 2.7 |
| [5] | African American | 1.4 |
| [4] | Kenya Nandi | 1.0 |
| [5] | Hispanic American | 0.6 |
| [5] | Caucasian American | 0.2 |
Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in African Americans.
gollark: By pulling down and attempting to parse the horrible mess of available data, we could see what people want for what.
gollark: I have a cool idea: scraping the trade hub periodically to get an idea of what people ask for on trades.
gollark: It's not as if Aeons *are* worth NDs.
gollark: I'm trying to collect whites/purples for a trade for a paper which is up now, but the AP is uncooperative.
gollark: Come on AP, give me whites or something already.
References
- Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- Allsopp CE, Hill AV, Kwiatkowski D, et al. (1991). "Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35". Hum. Immunol. 30 (2): 105–9. doi:10.1016/0198-8859(91)90078-N. PMID 2022493.
- derived from IMGT/HLA
- Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in
|title=(help) - Maiers M, Gragert L, Klitz W (2007). "High-resolution HLA alleles and haplotypes in the United States population". Hum. Immunol. 68 (9): 779–88. doi:10.1016/j.humimm.2007.04.005. PMID 17869653.
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