HLA-B59

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products.[1] B59 is a hybrid between B*55 and B*51.[2] B59 is more common in Japan, Korea, N. China and Mongolia. (For terminology help see: HLA-serotype tutorial)




major histocompatibility complex (human), class I, B59
Alleles	B*5901
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*5901
Locus	chr.6 6p21.31

Serotype

B59 serotype recognition of the HLA B*59 allele-group gene products[3]
B*59	B59	Other	Sample
allele	%	%	size (N)
5901	45	41	123

B*5901 allele frequencies

**HLA B*5901 frequencies**
		freq
ref.	Population	(%)
[4]	Okinawan (USA Hawaii)	6.3
[4]	Japan (2)	2.7
[4]	Tarialan Khoton (Mongolia)	2.4
[4]	South Korea (3)	2.1
[4]	Gipuscoa Basque (Spain)	2.0
[4]	Japan Central	1.8
[4]	Casablanca (Morocco)	1.8
[4]	Hyogo (Japan)	1.6
[4]	N. Korean (Harbin,China)	1.0
[4]	Manchu (Harbin, China)	0.6
[4]	Naxi (Yunnan, China)	0.6
[4]	Girona (Catalonia,Spain)	0.6
[4]	Algeria (1)	0.5
[4]	Inner Mongolia (China)	0.5
[4]	Khalkha (Mongolia)	0.5
[4]	Shanghai (China)	0.3
[4]	Essen (German )	0.3
[4]	Southern Han (China)	0.2
[4]	Shij. Tian. (Beijing, China)	0.1
[4]	Hakka (Taiwan)	0.1

**Regions of higher B*5901 frequency**
Japan
Korea
Mongolia
Heilongjiang prov., China (Harbin city)

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References

Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
Hildebrand WH, Domena JD, Parham P (1993). "Primary structure shows HLA-B59 to be a hybrid of HLA-B55 and HLA-B51, and not a subtype of HLA-B8". Tissue Antigens. 41 (4): 190–5. doi:10.1111/j.1399-0039.1993.tb02001.x. PMID 8362411.
derived from IMGT/HLA
Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)

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[pmid15787720-1] Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.

[pmid8362411-2] Hildebrand WH, Domena JD, Parham P (1993). "Primary structure shows HLA-B59 to be a hybrid of HLA-B55 and HLA-B51, and not a subtype of HLA-B8". Tissue Antigens. 41 (4): 190–5. doi:10.1111/j.1399-0039.1993.tb02001.x. PMID 8362411.

[3] rived from IMGT/HLA

[pmid12753660-4] Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)