Glycosylphosphatidylinositol phospholipase D

Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate
Glycosylphosphatidylinositol phospholipase D
Identifiers
EC number3.1.4.50
CAS number113756-14-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.

See also

References

  1. Low MG, Prasad AR (February 1988). "A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma". Proceedings of the National Academy of Sciences of the United States of America. 85 (4): 980–4. Bibcode:1988PNAS...85..980L. doi:10.1073/pnas.85.4.980. PMC 279684. PMID 3422494.
  2. Malik AS, Low MG (December 1986). "Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases". The Biochemical Journal. 240 (2): 519–27. PMC 1147446. PMID 3028377.
  3. Li JY, Hollfelder K, Huang KS, Low MG (November 1994). "Structural features of GPI-specific phospholipase D revealed by proteolytic fragmentation and Ca2+ binding studies". The Journal of Biological Chemistry. 269 (46): 28963–71. PMID 7961859.
  4. Deeg MA, Bierman EL, Cheung MC (March 2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". Journal of Lipid Research. 42 (3): 442–51. PMID 11254757.
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